Words similar to autoimmune
Example sentences for: autoimmune
How can you use “autoimmune” in a sentence? Here are some example sentences to help you improve your vocabulary:
While SSc is an autoimmune disease affecting microvasculature, some recent studies also described increased incidence of vascular pathology in the large arterial vessels of SSc patients [ 29 30 31 ] . However, it is still unclear if macro vascular pathology is a primary feature of SSc or an indirect effect of some of the downstream events related to this disease.
TNFα and TNFβ have been extensively studied and are involved in immune and pro-inflammatory responses, playing an important role in host defenses against infection and other disease states [ 4 5 6 7 ] . The biological effects of TNFα and TNFβ are mediated through the two membrane associated receptors, TNFR1 (p55) and TNFR2 (p75), that are expressed on the target cells [ 8 9 ] . The postulated pathogenic roles for TNF include sepsis and other bacterial and viral pathologies [ 10 11 12 ] , certain cancers [ 13 ] , metastasis [ 14 ] and chronic autoimmune disorders such as rheumatoid arthritis [ 15 16 ] , multiple sclerosis [ 17 ] and Crohn's disease [ 18 ] . It is worth noting that TNFα mutants have been identified that selectively bind TNFR1.
An over-representation of VH4 genes in the autoimmune repertoire has been described [ 7, 8].
Thus the advent of the CD8 +CD28 -cell in aging, with its potential for proinflammatory cytokines, could have profound effects not only on autoimmune diseases, but on Alzheimer's disease as well since cytokines may contribute to the neuropathology [ 72 ] .
Exclusionary laboratory values included a platelet count of > 500,000/mm 3, hematocrit <30%, and a white-blood-cell count < 3000/mm 3. Other exclusionary criteria included use of intravenous or intra-articular corticosteroids within four weeks of randomization, any prior use of cyclosporine or cyclophosphamide, use of any investigational agent within 30 days of randomization, severe extra-articular manifestations of RA, acute infection requiring antibiotic therapy within two weeks of randomization, other autoimmune disease (e.g.
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