Words similar to autoantigens
Example sentences for: autoantigens
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Among beta-cell autoantigens, GAD65 is an important initial target of the immune response that results in beta-cell destruction and diabetes, in both humans and NOD mice [ 6 7 8 9 ] . While both humoral and cellular responses to GAD65 occur as early as 4 weeks of age in NOD mice [ 8 ] , there is considerable evidence that beta-cell-specific T H 1 cells are the effectors of T1DM, whereas T H 2 cells appear to have a protective role [ 10 ] . Accordingly, a shift of the autoimmune response from T H 1 to T H 2 predominance has represented a promising strategy for prevention of diabetes and other T H 1-mediated autoimmune diseases.
An identical pattern of fragmentation was essentially observed for all the Golgi autoantigens examined except that the overall kinetics of native protein degradation was slower (data not shown).
The emerging view is that modified forms of autoantigens generated during cell death might stimulate autoantibody responses if presented to the immune system in a proinflammatory context [ 23 ] . Since the fate of the Golgi complex during cell death has not been extensively explored, we investigated whether the Golgi complex and associated autoantigens are altered during apoptosis and necrosis.
The caspase family of proteases plays a central role in apoptosis by participating in a cascade of cleavage events that result in the apoptotic phenotype [ 31 ] . We investigated whether the proteolysis of Golgi autoantigens caused by treatment with STS was caspase dependent.
The identified autoantigens referred to are golgin-160/GCP170 [ 7 8 ] , golgin-95/gm130 [ 7 ] , golgin-97 [ 9 ] , golgin-245/ p230 [ 10 11 12 ] , giantin/macrogolgin/GCP372 [ 13 14 ] , and golgin-67 [ 15 ] . These proteins are characterized by predominant α-helical coiled-coil domains, except for N-termini and C-termini.
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