Words similar to autoantigens
Example sentences for: autoantigens
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Among beta-cell autoantigens, GAD65 is an important initial target of the immune response that results in beta-cell destruction and diabetes, in both humans and NOD mice [ 6 7 8 9 ] . While both humoral and cellular responses to GAD65 occur as early as 4 weeks of age in NOD mice [ 8 ] , there is considerable evidence that beta-cell-specific T H 1 cells are the effectors of T1DM, whereas T H 2 cells appear to have a protective role [ 10 ] . Accordingly, a shift of the autoimmune response from T H 1 to T H 2 predominance has represented a promising strategy for prevention of diabetes and other T H 1-mediated autoimmune diseases.
Future experiments must be directed at a detailed analysis of tissue patterns of X inactivation, as well as at a search for potential X-linked autoantigens.
The emerging view is that modified forms of autoantigens generated during cell death might stimulate autoantibody responses if presented to the immune system in a proinflammatory context [ 23 ] . Since the fate of the Golgi complex during cell death has not been extensively explored, we investigated whether the Golgi complex and associated autoantigens are altered during apoptosis and necrosis.
Conceivably, skewed expression of X-linked autoantigens could play a role here, but this would require invoking a peripheral tolerizing compartment that is limiting with respect to the dosage of tolerizing cells to which peripheral T cells can be exposed.
Thus, this mechanism would not be expected to commonly lead to lack of tolerance unless there are at least several highly polymorphic X-linked autoantigens in the population that are involved in thymic deletion events.
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