Words similar to autoantigens

Example sentences for: autoantigens

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Thus, females may be predisposed to a situation in which they can occasionally express X-linked autoantigens in the periphery to which they have been inefficiently tolerized.
Casciola-Rosen and coworkers have proposed that modifications of autoantigens during cell death, particularly proteolytic cleavage, might be crucial for the generation of autoantibodies in autoimmune diseases [ 23 37 ] . Unique proteolytic fragments of α-fodrin and type 3 muscarinic acetylcholine receptor have been implicated in the generation of autoantibody responses in primary Sjögren's syndrome [ 38 39 ] .
The caspase family of proteases plays a central role in apoptosis by participating in a cascade of cleavage events that result in the apoptotic phenotype [ 31 ] . We investigated whether the proteolysis of Golgi autoantigens caused by treatment with STS was caspase dependent.
Future experiments must be directed at a detailed analysis of tissue patterns of X inactivation, as well as at a search for potential X-linked autoantigens.
Although we did not determine which golgins are substrates for specific caspases, further studies aimed at defining the caspases responsible for golgin cleavage, the cleavage sites, and the biological consequences of these cleavages should provide important insights into the possible role of some of the Golgi autoantigens in apoptosis.