Words similar to autoantigens
Example sentences for: autoantigens
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The identified autoantigens referred to are golgin-160/GCP170 [ 7 8 ] , golgin-95/gm130 [ 7 ] , golgin-97 [ 9 ] , golgin-245/ p230 [ 10 11 12 ] , giantin/macrogolgin/GCP372 [ 13 14 ] , and golgin-67 [ 15 ] . These proteins are characterized by predominant α-helical coiled-coil domains, except for N-termini and C-termini.
Within the past several years, our laboratories and others have cloned and identified novel Golgi autoantigens (golgins) [ 6 ] . This has been achieved primarily by expression cloning using human autoantibody probes.
Analysis of post-translational modifications in intracellular autoantigens associated with apoptosis and necrosis should provide important insights into the possible role of cell death in the generation of potentially autoantigenic forms of cellular antigens.
Thus, females may be predisposed to a situation in which they can occasionally express X-linked autoantigens in the periphery to which they have been inefficiently tolerized.
Among beta-cell autoantigens, GAD65 is an important initial target of the immune response that results in beta-cell destruction and diabetes, in both humans and NOD mice [ 6 7 8 9 ] . While both humoral and cellular responses to GAD65 occur as early as 4 weeks of age in NOD mice [ 8 ] , there is considerable evidence that beta-cell-specific T H 1 cells are the effectors of T1DM, whereas T H 2 cells appear to have a protective role [ 10 ] . Accordingly, a shift of the autoimmune response from T H 1 to T H 2 predominance has represented a promising strategy for prevention of diabetes and other T H 1-mediated autoimmune diseases.
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