Words similar to autoantigens
Example sentences for: autoantigens
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4), indicating that cleavage of Golgi autoantigens during apoptosis is mediated by caspases.
This again might lead to local epithelial cell microenvironments that fail to delete for X-linked autoantigens.
It has been speculated that these modified forms of autoantigens may have enhanced immunogenicity through exposure of immunocryptic epitopes that are not generated during antigen processing [ 21 23 37 43 ] . These epitopes could trigger autoimmune responses if presented to the immune system under proinflammatory conditions [ 44 ] , and they may be recognized as surface structures on cytoplasmic organelles that are released to the immune system in aberrant disease states.
The generation of proteolytic fragments from Golgi autoantigens was completely blocked in Jurkat cells pretreated with zVAD-fmk (Fig.
The present study has shown overall morphologic changes of the Golgi complex during apoptosis and necrosis, with distinct fragmentation patterns of its associated autoantigens.