Words similar to autoantigen
Example sentences for: autoantigen
How can you use “autoantigen” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, genes for human autoantigen and human carboxyl ester lipase-like protein would be considered up-regulated in the microarray (according to PM match hybridization) if the MM hybridization values were ignored in the fold change calculation.
This finding supports proposals that pre-B cells undergo positive selection directed by the presence of surface heavy chains with low albeit sufficient affinity to the autoantigen.
At present, the origin of their target autoantigen is not clear.
Although direct evidence that autoantigen cleavage fragments produced during cell death elicit autoantibody responses is still scarce, Pollard et al . reported that immunization of B10.S mice (H-2 s) with a 19 kDa proteolytic cleavage fragment of fibrillarin (derived from nonapoptotic cell death) elicited antibodies that are comparable with human anti-fibrillarin autoantibodies and those derived from mice exposed to mercury [ 40 ] . In a study using human sera, Greidinger et al . reported that the recognition of apoptosis-derived and oxidatively modified forms of the 70 kDa subunit of U1 small nuclear ribonucleoprotein autoantigen was associated with distinct disease manifestations [ 41 ] . Furthermore, Oriss et al . demonstrated that a combination of antigen-processing cells and a fragment of DNA topoisomerase I efficiently elicited autoreactive T-cell proliferation, whereas the full-length topoisomerase I required additional stimulus of exogenous interleukin-2 [ 42 ] .
Therefore, scientists have created induced models, often by exposing the animals to high doses of a suspected autoantigen at the same time as stimulating the immune system.
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