Words similar to appppa

Example sentences for: appppa

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AppppA is induced by heat shock in bacteria [ 36 ] and the induction of AppppA was thought to be a function of the heat-shock inducible LysU lysyl tRNA synthetase.
On the basis that Fhit binds diadenosine polyphosphates with one AMP group buried and the other adenosine solvent-exposed in a specific conformation [ 12 ] , effective tri and tetrapodal inhibitors such as 12b, 13b and HC(ADP) 3 [ 15 ] may exist in solution predominantly in a conformation that resembles Fhit-bound AppppA.
On the basis of observations [ 12 13 ] discussed above, one would expect AppppA with two phosphorothioadenosyl substituents to be a slow substrate with a relatively low K m . However, carbon in place of the β phosphorus (for example in 6b ) would make the leaving group the alkoxide - OCH 2 -CH(OH)-CH 2 O-phosphorothioadenosyl rather than α-thio ATP.
In the case of disruption of the Fhit and Hnt2-homologous aph1 gene in S. pombe , which encodes an enzyme relatively specific for a AppppA [ 20 ] , a 290-fold increase in AppppA concentration was observed [ 22 ] . Our data indicate that Hnt2 hydrolyzes ApppN and AppppN in vivo in budding yeast and that an intact adenine biosynthetic pathway is required for high-level synthesis and accumulation of adenylylated dinucleoside polyphosphates.
Fhit proteins from humans [ 19 ] and worms [ 15 ] bind ApppA and AppppA with K m values of 2 to 3 μM.