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Example sentences for: appppa

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Covalent structures of AppppA ( 1 ) and compounds 6b and 12b are provided in Figure 1.
If the substrate-dependent signaling model is correct, then compound 6b, as a nearly isosteric AppppA analog with a low K i , may promote Fhit signaling in Fhit+ cells.
On the basis that Fhit binds diadenosine polyphosphates with one AMP group buried and the other adenosine solvent-exposed in a specific conformation [ 12 ] , effective tri and tetrapodal inhibitors such as 12b, 13b and HC(ADP) 3 [ 15 ] may exist in solution predominantly in a conformation that resembles Fhit-bound AppppA.
On the basis of observations [ 12 13 ] discussed above, one would expect AppppA with two phosphorothioadenosyl substituents to be a slow substrate with a relatively low K m . However, carbon in place of the β phosphorus (for example in 6b ) would make the leaving group the alkoxide - OCH 2 -CH(OH)-CH 2 O-phosphorothioadenosyl rather than α-thio ATP.
Fhit proteins from humans [ 19 ] and worms [ 15 ] bind ApppA and AppppA with K m values of 2 to 3 μM.