Words similar to antagonistic
Example sentences for: antagonistic
How can you use “antagonistic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Recent experiments indicate that synergistic and antagonistic interactions are both common when pairs of mutations are considered, but that, overall, the two types of interactions either roughly cancel each other out or perhaps even produce an excess of antagonistic interactions [ 20 21 22 23 24 25 26 27 28 29 ] . Only one study of this type reported an excess of synergistic interactions [ 30 ] . Moreover, two simple systems with computational landscapes, self-replicating computer programs [ 2 ] and RNA secondary structure folding [ 11 ] , both exhibited a clear excess of antagonistic interactions.
However, our findings do indicate that compensatory mutations can play a major role in producing antagonistic epistasis and thus slowing the decay in mean fitness under random mutation accumulation.
Still, other reports, have suggested that opioid ligands with agonistic effect at μ opioid receptors and antagonistic effect at δ opioid receptors are potentially useful analgesics [ 3 17 18 ] . These latter results advocate that the key to designing opioid ligands with optimal analgesia and minimal side effects may be in the design of ligands that act on more than one receptor type, but activate each receptor differently.
To date several antagonistic protein reagents have been isolated for treating diseases with an underlying TNF etiology.
The definition is not as important as the substantive conclusion: The fact that it is possible to restore a previously existing structure by many non-trivial mutational pathways is sufficient to cause pronounced antagonistic directional epistasis.
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