Words similar to antagonism
Example sentences for: antagonism
How can you use “antagonism” in a sentence? Here are some example sentences to help you improve your vocabulary:
Since clozapine crosses the blood-brain barrier readily [ 14 ] , the maximum dose selected in the present experiment was restricted to the first appearance of a decrease in blood pressure as an indication of possible peripheral alpha 1 antagonism due to peripheral leakage.
However, intrathecal atipamezole (alpha2 antagonist) increased residual volume in awake rats [ 18 ] . Therefore, it is difficult to interpret clozapine's effects on micturition volume in terms of spinal alpha adrenoceptor antagonism and possibly the supraspinal effects predominate.
For example some investigators have suggested that opioid ligands with agonism at μ opioid receptors and antagonism at δ opioid receptors are potentially useful analgesics [ 5 6 7 ] . In cases where the medicinal effect of a drug is mediated through the same opioid receptor type that also elicits the side effects, the use of drugs with mixed activity could be most beneficial [ 7 ] . In such a case, interaction with one receptor could reverse the unwanted side effects associated with activation of the other receptor.
The primary clinical utility of RU486 is PR antagonism to induce early pregnancy abortion.
Voltage-gated K +currents with distinct electrophysiological and pharmacological properties are present in granulosa cells (GC), and modulate resting membrane potential [ 4 12 13 16 17 ] . Furthermore, selective antagonism of GC K +channels with distinct molecular correlates, electrophysiological properties and expression patterns can influence differentially GC proliferation, steroidogenic capability, and apoptosis [ 17 18 ] . Our laboratory has previously identified two distinct delayed rectifier K +currents in pig GC: a slow current (I Ks ) associated with channels formed by co-assembly of KCNQ1 pore-forming and KCNE1 accessory proteins, and an ultra-rapid current (I Kur ) formed by co-assembly of KCNA pore-forming and KCNAB accessory proteins [ 4 ] . Moreover, we have shown that selective block of I Ks enhances basal progesterone synthesis, while complete block of both I Ks and I Kur accelerates apoptosis [ 18 ] .
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