Example sentences for: antagonism

How can you use “antagonism” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In anesthetized rats, doxazosin (alpha 1 adrenergic receptor antagonist) administered systemically, increased micturition volume, bladder capacity, residual volume and micturition frequency while decreasing peak pressure [ 36 ] . Only an increase in the micturition frequency was observed after spinal administration of doxazosin [ 37 ] . Both olanzapine and risperidone have moderate affinity for the alpha 1 adrenergic receptor (Table 1), therefore it is possible that some of the effects observed in the present study were due to central and/or peripheral antagonism of alpha 1 adrenergic receptors by these drugs.

  • Certainly I see…antagonism of some of these pathways that nicotine activates or the complementary activation of the cannabinoid pathways as very important targets for therapeutics with respect to the anorexia that's associated with chemotherapy.”

  • 4-aminopyridine, at millimolar concentrations, completely inhibits K +currents conducted by heterologously expressed KCNA channels and native GC I Kur , but lacks significant effects on native GC I Ks [ 4 12 13 20 ] . Kusaka showed that antagonism of 4-AP sensitive slowly inactivating delayed rectifier K +currents suppressed both basal and luteinizing hormone (LH)-stimulated progesterone production [ 21 ] . In this report, we extend those findings by demonstrating 4-AP inhibition of follicle stimulating hormone (FSH)-stimulated progesterone production, and by elucidating the underlying mechanisms.

  • Earlier, we presented evidence that a regulator of G protein signaling, RGS3, might participate in the regulation of GnRH receptor signaling [ 9 ] . The mechanism of RGS action is antagonism of the Gα protein either by accelerating its hydrolysis of GTP, thereby prematurely terminating signaling due to reassociation of the Gα and Gβγ complexes [ 10 ] , or by antagonizing interaction of the Gα protein with its effector such as phospholipase Cβ [ 11 12 ] . A large number of RGS genes have been identified in mammals based on the presence of a 120 amino acid core domain [ 13 14 15 16 ] . RGS proteins have been described that interact with the G i α and G qα members of the G protein family [ 17 18 19 20 21 ] .

  • By allowing random mutations to accumulate only in surviving lineages, a researcher may inadvertently bound mean fitness away from zero, and thereby bias the shape of the fitness function versus mutation number from synergy toward antagonism.


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