Example sentences for: antagonist

How can you use “antagonist” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • IL-4 can downregulate the production of proinflammatory and T-helper (Th)1-type cytokines by inducing mRNA degradation and upregulating the expression of inhibitors of proinflammatory cytokines such as IL-1 receptor antagonist (IL-1Ra) [ 3, 4].

  • DMEM = Dulbecco's modified Eagle medium; ELISA = enzyme-linked immunosorbent assay; FBS = fetal bovine serum; HSF = human synovial fibroblast; (r/t)IL-1Ra = (recombinant/transgenic) IL-1 receptor antagonist; OA = osteoarthritis; PBS = phosphate-buffered saline; PGE 2 = prostaglandin E 2 ; RA = rheumatoid arthritis.

  • As such, the primary structure of a Tlr4 molecule determines ligand specificity [ 13], accounting for the well-known observation that mouse cells can recognize tetra-acyl lipid A as an agonist [ 20] whereas human cells recognize it as an antagonist [ 20, 21, 22, 23, 24].

  • All mutant receptors were tested for their ability to bind the 5-HT 3 R antagonist [ 3H]granisetron.

  • In cats, serotonin antagonists caused a decrease in bladder capacity [ 43 ] however in anesthetized rats, serotonin antagonism did not have an effect on micturition [ 44 ] . Recently, a selective 5-HT1A receptor antagonist (WAY-100635) was reported to inhibit bladder contractions in rats [ 45 ] yet another report only observed an increase in the pressure threshold [ 46 ] . Olanzapine and risperidone have only low to modest affinity for the 5-HT1A receptor, and higher affinities for the 5-HT2A and 5-HT2C receptors [ 11 12 ] . Serotonin 5-HT2 and 5-HT3 receptors facilitate pudendal reflexes in the cat [ 47 48 ] , therefore it is possible that antagonism of these receptors may block the EUS in the anesthetized rat.


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