Words similar to angiotensin
Example sentences for: angiotensin
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have demonstrated that spontaneously hypertensive rats(SHR) with symptoms of heart failure had significantly higher levels ofapoptotic myocytes than control myocytes [ 37 ] .When treated with an angiotensin-converting enzyme inhibitor, thenumber of apoptotic cells in the SHR with symptoms of heart failurewas dramatically reduced to control levels; controls were SHR withoutsymptoms of heart failure [ 37 ] . Kajstura et al.have also reported that angiotensin II increased the percentageof apoptotic cells in isolated adult rat ventricular myocytes, andthis effect was mediated by AT-1 receptors [ 38 ] .Although ventricular function was not assessed in these studies,the observations raise the possibility that, like our findings withcarvedilol, the beneficial effect of ACE-inhibitors or AT-1 receptorblockers in heart failure may in part be attributed to an inhibitionof myocyte apoptosis with a resultant improvement in in vivo cardiacfunction, a concept that needs further study.
The presence of the Factor V Leiden mutation and the deletion-deletion polymorphism of the angiotensin converting enzyme gene were determined for 38 patients who developed symptomatic pulmonary embolism (30 patients) or proximal deep venous thrombosis (8 patients) following elective total hip or knee arthroplasty at our institution between February of 1997 and July of 1999.
Conflicting results have been reported from studies on the stroke risk factor status of genes related to myocardial infarction or arterial disease, such as specific genotypes of the genes for angiotensin 1-converting enzyme ( ACE ) [ 23 24 25 26 ] or apolipoprotein [ 27 28 29 30 31 32 33 34 ] . Potential confounding factors include the effects of comorbidity and differential mortality rates [ 34 35 ] . Although the degree of stenosis of the cervical internal carotid arteries in symptomatic patients correlates with risk of ipsilateral stroke [ 36 ] , no clear conclusions can be drawn from attempts to relate carotid artery disease to specific genotypes (for example, of the paraoxonase gene PON, which is thought to protect low-density lipoprotein against oxidative modification [ 37 ] , or of the endothelial nitric oxide synthase gene [ 38 ] ).
[ 23] found no association between the Factor V Leiden mutation and deep venous thrombosis, they did find that the deletion-deletion genotype of the angiotensin converting enzyme was strongly associated with postoperative venous thrombosis in 85 patients who had undergone total hip arthroplasty (30 of whom had a thromboembolic event as detected by routine compression duplex ultrasound).
Other medications shown to possibly delay or prevent the onset of type 2 diabetes are ACE-I and angiotensin II receptor blockers [17,18].
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