Words similar to angiotensin
Example sentences for: angiotensin
How can you use “angiotensin” in a sentence? Here are some example sentences to help you improve your vocabulary:
Other medications shown to possibly delay or prevent the onset of type 2 diabetes are ACE-I and angiotensin II receptor blockers [17,18].
The activation of p38 and JNK pathways by angiotensin II and endothelin occurs at higher concentrations of agonist and requires a longer incubation with the stimulus [ 18 19 25 ] . There are data which also suggest that different signal transduction pathways are utilized for the different pathways [ 25 26 27 ] . This differential activation of MAPK pathways is most likely due to the role that each plays in the cell.
have demonstrated that spontaneously hypertensive rats(SHR) with symptoms of heart failure had significantly higher levels ofapoptotic myocytes than control myocytes [ 37 ] .When treated with an angiotensin-converting enzyme inhibitor, thenumber of apoptotic cells in the SHR with symptoms of heart failurewas dramatically reduced to control levels; controls were SHR withoutsymptoms of heart failure [ 37 ] . Kajstura et al.have also reported that angiotensin II increased the percentageof apoptotic cells in isolated adult rat ventricular myocytes, andthis effect was mediated by AT-1 receptors [ 38 ] .Although ventricular function was not assessed in these studies,the observations raise the possibility that, like our findings withcarvedilol, the beneficial effect of ACE-inhibitors or AT-1 receptorblockers in heart failure may in part be attributed to an inhibitionof myocyte apoptosis with a resultant improvement in in vivo cardiacfunction, a concept that needs further study.
The initial increase in circulating norepinephrineis thought to maintain cardiac function through inotropic mechanisms.However, a direct cardiac myocyte toxicity from norepinephrine iswell recognized [ 6 7 ] . Furthermore, pressure-overloadand stretch associated release of angiotensin II has been shownto induce myocyte apoptosis [ 8 9 10 ] .In an elegant paper by Telger et al.
The p38 pathway has demonstrated a different time course of activation via G- protein coupled receptors than the ERK pathway [ 24 ] . Using the time point (30 min) at which angiotensin II demonstrates maximal stimulation of the JNK pathway we performed a concentration response curve (10 -9- 10 -5M) to 5-HT in vascular smooth muscle cells.
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