Example sentences for: angiogenic

How can you use “angiogenic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Not surprisingly, a recent report that assessed the angiogenic response in a murine corneal pocket model to a fixed dosage of FGF-2 in various strains of mice suggested that genetic backgrounds may influence angiogenic response [ 30].

  • Some CXC chemokines, such as IL-8 and cCAF, are angiogenic in vivo [ 3 39 40 41 ] . Others, such as IP-10 (interferon-γ10) and PF-4 (platelet factor-4), are anti-angiogenic.

  • Although protein therapy has many advantages, there are nevertheless technical problems associated with protein administration, including optimization of purification and formulation of delivery for single and/or multiple angiogenic factors.

  • Tie1 is an orphan receptor, whereas the ligands of Tie2 receptor have been identified as angiopoietin (Ang)-1 and Ang-2 [ 5 6 ] . Ang-1 has been shown to be responsible for recruiting and sustaining periendothelial support cells [ 7 ] . It has been reported that Ang-2 disrupts blood vessel formation in the developing embryo by antagonizing Ang-1-induced autophosphorylation of Tie2 [ 6 ] . Transgenic mouse models of Tie2/Ang-1 result in embryonic lethality due to absence of remodeling and sprouting of blood vessels [ 7 8 ] . The physiologic roles of the Tie2 receptor and its ligands are limited to angiogenic processes that occur subsequently to the earlier vasculogenic and angiogenic actions of vascular endothelial growth factor (VEGF) and its receptors [ 7 ] . VEGF and the Tie family orchestrate optimal blood vessel formation [ 9 10 ] .

  • A nearly 10-fold range of response to the fixed dosage of FGF-2 was observed among different inbred strains of mice, suggesting that genetic variability may indeed play a significant role in determining the magnitude of angiogenic response to FGF-2.


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