Words similar to angiostatic
Example sentences for: angiostatic
How can you use “angiostatic” in a sentence? Here are some example sentences to help you improve your vocabulary:
MIG/CXCL9 and IP-10/CXCL10 are potent angiostatic factors that are induced by IFNγ [ 14 16 17 ] . Both MIG/CXCL9 and IP-10/CXCL10 are chemotactic for stimulated CXCR3-expressing activated T lymphocytes that could further amplify IFNγ at the tumor site [ 30 ] . Hence we postulated that in addition to IFNγ, IP-10/CXCL10 and MIG/CXCL9 would also be important contributors to the tumor reduction in the context of SLC/CCL21 therapy.
Thus, large tumours that are richly vascularised might be more sensitive to angiostatic therapy.
SLC/CCL21, a CC chemokine expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts naive T cells and DCs [ 1 2 3 4 5 6 7 8 ] . Because DCs are potent APCs that function as principal activators of T cells, the capacity to facilitate the co-localization of both DC and T cells may reverse tumor-mediated immune suppression and orchestrate effective cell-mediated immune responses [ 9 10 25 26 27 ] . In addition to its immunotherapeutic potential, SLC/CCL21 has been found to have potent angiostatic effects [ 28 ] , thus adding further support for its use in cancer therapy.
It is also noteworthy that treatment with the endostatin vector, which results in a much higher level of the angiostatic protein (1-3 μg / ml), does not significantly reduce the number of metastases.
endostatin, angiostatin, thrombospondin) differ in their angiostatic activity from synthetic inhibitors, since they appear to also block endothelial cell proliferation and/or migration.
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