Example sentences for: androgen-mediated

How can you use “androgen-mediated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Importantly, SKP2 overexpression is sufficient to reverse androgen-mediated p27 accumulation and induce p27 ubiquitylation (Fig.

  • Finally, consistent with SKP2 and p27 being integral components of androgen-mediated growth control of LNCaP cells, CA also efficiently reversed the MIB-induced G1 cell cycle arrest (Fig.

  • This interpretation is consistent with SKP2 being a proximal element in the previously identified androgen-mediated pathway of cell cycle inhibition in LNCaP cells.

  • Such a mediator could be AS3, a gene induced by growth inhibiting levels of androgen with kinetics that precede cell cycle arrest [ 52 ] . In addition, AS3 overexpression mimics androgen-mediated cell cycle arrest in MCF7 cells stably expressing exogenous AR, while anti-sense AS3 confers resistance to androgen-induced growth arrest [ 53 ] . The function of AS3 is still unknown, but the encoded protein has features of a potential transcription factor [ 53 ] .

  • SKP2 overexpression is sufficient to overcome androgen-mediated p27 accumulation, indicating that it is a major mediator of androgen-mediated cell cycle control.


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