Words similar to androgen-mediated

Example sentences for: androgen-mediated

How can you use “androgen-mediated” in a sentence? Here are some example sentences to help you improve your vocabulary:

This interpretation is consistent with SKP2 being a proximal element in the previously identified androgen-mediated pathway of cell cycle inhibition in LNCaP cells.
Such a mediator could be AS3, a gene induced by growth inhibiting levels of androgen with kinetics that precede cell cycle arrest [ 52 ] . In addition, AS3 overexpression mimics androgen-mediated cell cycle arrest in MCF7 cells stably expressing exogenous AR, while anti-sense AS3 confers resistance to androgen-induced growth arrest [ 53 ] . The function of AS3 is still unknown, but the encoded protein has features of a potential transcription factor [ 53 ] .
Importantly, SKP2 overexpression is sufficient to reverse androgen-mediated p27 accumulation and induce p27 ubiquitylation (Fig.
4C), we conclude that SKP2 directly triggers the ubiquitylation and degradation of p27 in LNCaP cells, a process which is attenuated by androgen-mediated SKP2 downregulation.
Future studies aimed at eliminating CSN5 activity will show whether it is involved in androgen-mediated p27 control.