Words similar to androgen-responsive

Example sentences for: androgen-responsive

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An additional set consists of 30 androgen-responsive genes with roles in protein trafficking and secretory vesicle formation and in transport of secretory vesicles (Figure 5a).
Stat3 has been shown to enhance AR-mediated PSA expression and AR transcriptional activity in prostate cancer cells [ 16 25 28 ] . We used two well-characterized androgen-responsive luciferase reporter plasmids to study the effect of Stat3 on AR-mediated transcriptional activity.
et al . found significantly different baseline expression levels of insulin-like growth factor (IGF) and insulin-like growth factor binding protein (IGFBP) between normal and AIS-derived genital skin fibroblasts, and could not detect changes in transcript levels in response to androgen treatment [ 29 ] . In normal genital fibroblasts, androgen-responsive reporter genes can only be activated by expression of co-transfected AR in the presence of ligand [ 30 ] . Therefore, endogenous AR expression itself may be insufficient in genital skin fibroblasts to elicit a transcriptional response.
CV-1 cells showed a strong response to R1881 compared to vehicle-treated cells with both androgen-responsive reporters used (Fig.
We were curious to know whether the expression changes observed in LNCaP would also occur in other androgen-responsive human prostate cancer cell lines (MDA PCa 2a, MDA PCa 2b, and LAPC-4), or in LNCaP and LAPC-4 subclones carried in androgen-depleted conditions for extended periods.