Example sentences for: androgens

How can you use “androgens” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Our earlier findings including a reduced number of elongated spermatids in the ABP-TG mice [ 26 ] also support the notion that higher than physiological concentrations of ABP affect spermatogenesis indirectly, through sequestration of androgens; the transformation of round spermatids to elongated spermatids is known to be the main androgen-dependent step in spermatogenesis [ 35 36 37 ] .

  • The effects of androgens are cell-specific and developmental stage-specific.

  • However, we were unable to detect any significant changes in gene-expression patterns in cultured, AR-expressing genital fibroblasts or in AIS-derived fibroblasts in response to androgens.

  • Several possible mechanisms have been suggested to explain this activation of AR, including mutations in the gene encoding AR that alter the specificity for androgens, overexpression of the AR protein itself, cross-talk to other signal transduction pathways, and altered levels or activity of coactivators [ 21 22 23 ] . Several groups including ours have demonstrated a role of activated Stat3 in the proliferation and survival of prostate cancer cells by a mechanism that involves the AR [ 24 25 26 27 28 ] .

  • This tendency towards autoimmunity in females is often ascribed to hormonal differences because, in a number of experimental disease models, estrogens exacerbate disease and androgens can inhibit disease activity [ 3, 4].


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