Words similar to androgens

Example sentences for: androgens

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Another possible mechanism by which a prostate cancer circumvents the low levels of androgens resulting from androgen ablation therapy is by increasing the sensitivity of AR to very low levels of androgens [ 42 ] . Stat3 increased the sensitivity of AR to a dose of androgen that showed no activity in the absence of Stat3, in the absence of a mutated AR.
Several possible mechanisms have been suggested to explain this activation of AR, including mutations in the gene encoding AR that alter the specificity for androgens, overexpression of the AR protein itself, cross-talk to other signal transduction pathways, and altered levels or activity of coactivators [ 21 22 23 ] . Several groups including ours have demonstrated a role of activated Stat3 in the proliferation and survival of prostate cancer cells by a mechanism that involves the AR [ 24 25 26 27 28 ] .
Like all steroid hormones, androgens act by binding to a nuclear hormone receptor, enacting conformational changes that allow binding of the receptor to specific regulatory elements in AR-responsive genes.
When androgens are given, these abnormalities are reversed and the clinical picture improves [ 30, 31].
However, we were unable to detect any significant changes in gene-expression patterns in cultured, AR-expressing genital fibroblasts or in AIS-derived fibroblasts in response to androgens.