Words similar to androgen-induced

Example sentences for: androgen-induced

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Such a mediator could be AS3, a gene induced by growth inhibiting levels of androgen with kinetics that precede cell cycle arrest [ 52 ] . In addition, AS3 overexpression mimics androgen-mediated cell cycle arrest in MCF7 cells stably expressing exogenous AR, while anti-sense AS3 confers resistance to androgen-induced growth arrest [ 53 ] . The function of AS3 is still unknown, but the encoded protein has features of a potential transcription factor [ 53 ] .
Whether it functions in the processing of androgen-induced secretory proteins or in other pathways induced by androgens or perhaps even in cell-cell signaling is unclear, but the degree of induction suggests it may have an important role in prostatic physiology.
Further investigation into androgen-induced changes in gene and protein expression in vitro and in vivo will undoubtedly shed light on prostatic physiology and prostatic carcinoma, and also on broader physiological functions of androgen.
Yet other pathways may not be direct targets of AR activation but could be modulated in response to androgen-induced changes in the internal or external milieu of the cells.
Unlike in rat fibroblasts and human U87 cells [ 29 30 32 ] , SKP2 overexpression is not sufficient to override androgen-induced G1 arrest in LNCaP cells, despite a profound effect on p27 levels (Fig.