Example sentences for: androgen-independent

How can you use “androgen-independent” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Most patients respond initially to androgen deprivation or antiandrogen regiments, but eventually the tumor relapses in an androgen-independent stage with a poor outcome.

  • We have observed consistent and characteristic differences in the gene-expression patterns of skin fibroblasts derived from different locations on the body [ 11 ] . However, the current set of experiments suggests that the androgen receptor has a cell-autonomous role which contributes to a stable androgen-independent gene-expression pattern in genital fibroblasts.

  • For further discrimination of androgen-independent positional effects from prenatal androgen actions on expression phenotypes of genital fibroblast strains, comparative expression profiling of homologous genital tissues is needed.

  • AKT1 is over-expressed in gastric adenocarcinomas and breast cancer cell lines, AKT2 is amplified and over-expressed in pancreatic, ovarian, and breast cancers, and AKT3 is upregulated in estrogen receptor-deficient breast cancer and in androgen-independent prostate cell lines [reviewed in ref.

  • Our data suggest that in addition to androgen-independent positional influences on fibroblast phenotypes, the AR is originally involved in establishing stable and reproducible patterns of gene expression in stromal cells during genital differentiation, which are reflected in the differences in global gene-expression patterns between fibroblasts cultured from the genital skin of normal individuals and females affected by AIS.


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