Words similar to alpha-crystallin
Example sentences for: alpha-crystallin
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AlphaB was found to be expressed at significant levels in a variety of nonlenticular tissues, while alphaA has only been detected in small amounts in a few other tissues such as retina, spleen and thymus [ 8 9 10 11 12 ] . Collectively, these findings have challenged the dogma that alpha-crystallin is purely a structural protein necessary for light refraction, and have led to the realization that alpha-crystallin may have a variety of biological functions in the lens.
The objectives of the current report were to characterize gross morphology of young (5 wk) and old (54 wk) mouse lenses with targeted disruption of both the alphaA and alphaB genes, in comparison to age matched wild type lenses, using scanning electron microscopy (SEM) and confocal microscopy, to elucidate the possible functions of alpha-crystallin in the lens.
Both alphaA and alphaB can bind specifically to actin, both in vitro [ 13 ] and in vivo [ 14 ] . Actin filament formation has been shown to be necessary for the differentiation of lens epithelial cells [ 15 ] , however, the significance of alpha-crystallin interaction with actin in differentiation is not known.
All of these findings raise many questions as to the possible role(s) of alpha-crystallin in the nucleus and in cell cycle regulation during differentiation.
Several heat shock proteins have been found in cell nuclei in the absence of stress [ 30 ] , and alpha-crystallin has been shown to interact directly with DNA [ 18 ] . AlphaB, expressed in transfected CHO cells, has been shown to ectopically localize to interphase nuclei, suggesting a regulatory role for this protein in the nucleus [ 19 ] . A subset of immortalized lens epithelial cells from alphaBKO mice have been shown to hyperproliferate [ 20 ] suggesting that alphaB may be important in maintaining genomic stability.
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