Example sentences for: alpha-crystallin

How can you use “alpha-crystallin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • One approach to resolving some of the in vivo functions of alpha-crystallin is to generate animal models where one or both of the alpha-crystallin gene products have been eliminated.

  • AlphaB was found to be expressed at significant levels in a variety of nonlenticular tissues, while alphaA has only been detected in small amounts in a few other tissues such as retina, spleen and thymus [ 8 9 10 11 12 ] . Collectively, these findings have challenged the dogma that alpha-crystallin is purely a structural protein necessary for light refraction, and have led to the realization that alpha-crystallin may have a variety of biological functions in the lens.

  • In the single alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the functions of the missing protein, especially in the lens, where both alphaA and alphaB are normally expressed at high levels.

  • The results indicate that alpha-crystallin is necessary for proper fiber cell formation and resulting lens transparency.

  • During the early 1990's, alpha-crystallin was shown to act as a molecular chaperone, binding to partially denatured proteins, both in vitro [ 5 ] and probably in vivo [ 6 ] , to inhibit further denaturation and aggregation of lens proteins.


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