Example sentences for: alpha-crystallin

How can you use “alpha-crystallin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The exact in vivo molecular mechanisms, by which alpha-crystallin might influence lens epithelial cell differentiation, and maintenance of lens transparency, remain to be determined.

  • In addition, it was clearly evident that alpha-crystallin is necessary for lens transparency.

  • Stress proteins have been shown to be expressed in non-stressed cells during development and differentiation [ 25 ] . Hsps were shown to be expressed during the differentiation of mammalian osteoblasts and promelocytic leukemia cells [ 26 ] . In addition, hsp expression has been shown to accompany growth arrest in human B lymphocytes [ 27 ] and macrophage differentiation of HL 60 cells [ 28 ] . During myogenic differentiation, mRNA for alphaB increases in conjunction with the induction of mRNA for myogenin, the earliest known event in myogenesis [ 29 ] . The addition of exogenous alpha-crystallin to primary bovine lens epithelium was shown to induce rapid changes in cell shape, leading to the formation of lentoid bodies [ 21 ] . These studies strongly suggest that the hsp family of proteins has other functions in addition to protecting proteins and cells during stress.

  • In the lens, alpha-crystallin also associates with type III intermediate filament proteins and the beaded filament proteins CP49 and CP115, and correct beaded filament assembly has been shown depend on the presence of alpha-crystallin [ 16 ] . Beaded filament mRNA levels are greatly increased in differentiating lens epithelium and have been suggested as a pan-specific marker for lens fiber development [ 17 ] . Alpha-crystallin has also been shown to interact directly with DNA [ 18 ] . In transfected CHO cells, alphaB has also been shown to ectopically localize to interphase nuclei, suggesting a role for this protein in the nucleus [ 19 ] . A nuclear role for alphaB in the lens was supported by the findings that a subset of lens epithelial cells derived from alphaB knockout mice demonstrated hyperproliferation and genomic instability [ 20 ] . In addition, the administration of exogenous alpha-crystallin to primary bovine lens epithelial cell cultures resulted in the formation of lentoid bodies, consistent with a role for these proteins in lens differentiation [ 21 ] . These findings indicate that alpha-crystallin may have a multitude of in vivo functions.

  • In the single alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the functions of the missing protein, especially in the lens, where both alphaA and alphaB are normally expressed at high levels.


How many words do you know? Try our free vocabulary size test!


Search

Search for example sentences

Loading Loading...
Quantcast