Words similar to alpha-crystallin
Example sentences for: alpha-crystallin
How can you use “alpha-crystallin” in a sentence? Here are some example sentences to help you improve your vocabulary:
The objectives of the current report were to characterize gross morphology of young (5 wk) and old (54 wk) mouse lenses with targeted disruption of both the alphaA and alphaB genes, in comparison to age matched wild type lenses, using scanning electron microscopy (SEM) and confocal microscopy, to elucidate the possible functions of alpha-crystallin in the lens.
In the single alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the functions of the missing protein, especially in the lens, where both alphaA and alphaB are normally expressed at high levels.
The results of the current study support the hypothesis that alpha-crystallin plays an active role in the differentiation and growth of lens fiber cells.
AlphaA and alphaB are members of the shsp family [ 7 ] . Previous studies have shown that the alpha-crystallin possesses molecular chaperone activity, binding to partially denatured proteins, both in vitro [ 5 ] and probably in vivo [ 6 ] , to inhibit further denaturation.
The exact in vivo molecular mechanisms, by which alpha-crystallin might influence lens epithelial cell differentiation, and maintenance of lens transparency, remain to be determined.
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