Example sentences for: alpha-crystallin

How can you use “alpha-crystallin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • One approach to resolving some of the in vivo functions of alpha-crystallin is to generate animal models where one or both of the alpha-crystallin gene products have been eliminated.

  • AlphaB was found to be expressed at significant levels in a variety of nonlenticular tissues, while alphaA has only been detected in small amounts in a few other tissues such as retina, spleen and thymus [ 8 9 10 11 12 ] . Collectively, these findings have challenged the dogma that alpha-crystallin is purely a structural protein necessary for light refraction, and have led to the realization that alpha-crystallin may have a variety of biological functions in the lens.

  • AlphaA and alphaB are members of the shsp family [ 7 ] . Previous studies have shown that the alpha-crystallin possesses molecular chaperone activity, binding to partially denatured proteins, both in vitro [ 5 ] and probably in vivo [ 6 ] , to inhibit further denaturation.

  • The exact in vivo molecular mechanisms, by which alpha-crystallin might influence lens epithelial cell differentiation, and maintenance of lens transparency, remain to be determined.

  • AlphaA and alphaB were also shown to have sequence homology with several other proteins that are members of the small heat shock protein (hsp) family [ 7 ] . Moreover, expression of alpha-crystallin, particularly alphaB, was shown to not be restricted to the lens.


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