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Example sentences for: alphab

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None of these morphological differences have been reported in the single alphaA or alphaB knockout mice.
The relative proportion of alphaA and alphaB changes from a molar ratio of 1:3 in the pericentral and germative zones to a molar ratio of 3:1 in the elongation zone and fiber cells [ 2 3 ] . These differences in the relative proportions of alphaA and alphaB within the lens suggest different functions for the two subunits in the developing lens.
AlphaB was found to be expressed at significant levels in a variety of nonlenticular tissues, while alphaA has only been detected in small amounts in a few other tissues such as retina, spleen and thymus [ 8 9 10 11 12 ] . Collectively, these findings have challenged the dogma that alpha-crystallin is purely a structural protein necessary for light refraction, and have led to the realization that alpha-crystallin may have a variety of biological functions in the lens.
AlphaA and alphaB were also shown to have sequence homology with several other proteins that are members of the small heat shock protein (hsp) family [ 7 ] . Moreover, expression of alpha-crystallin, particularly alphaB, was shown to not be restricted to the lens.
[ 22 ] demonstrated, by targeted disruption of the mouse alphaA gene, that this protein was essential for the maintenance of lens transparency, possibly by maintaining the solubility of alphaB, or associated proteins, in the lens.