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Example sentences for: alphab
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In the single alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the functions of the missing protein, especially in the lens, where both alphaA and alphaB are normally expressed at high levels.
AlphaA and alphaB were also shown to have sequence homology with several other proteins that are members of the small heat shock protein (hsp) family [ 7 ] . Moreover, expression of alpha-crystallin, particularly alphaB, was shown to not be restricted to the lens.
Both alphaA and alphaB can bind specifically to actin, both in vitro [ 13 ] and in vivo [ 14 ] . Actin filament formation has been shown to be necessary for the differentiation of lens epithelial cells [ 15 ] , however, the significance of alpha-crystallin interaction with actin in differentiation is not known.
Alpha-Crystallin is comprised of two polypeptides, alphaA-crystallin (alphaA) and alphaB-crystallin (alphaB), which share 55% amino acid sequence homology [ 1 ] . They are the most abundant proteins in lens fiber cells [ 2 3 ] and exist as heteroaggregates of approximately 800 kDa that can undergo inter-aggregate subunit exchange [ 4 ] . The expression of these two proteins in the lens epithelium, however, is not uniform throughout different regions of the anterior epithelium.
Several heat shock proteins have been found in cell nuclei in the absence of stress [ 30 ] , and alpha-crystallin has been shown to interact directly with DNA [ 18 ] . AlphaB, expressed in transfected CHO cells, has been shown to ectopically localize to interphase nuclei, suggesting a regulatory role for this protein in the nucleus [ 19 ] . A subset of immortalized lens epithelial cells from alphaBKO mice have been shown to hyperproliferate [ 20 ] suggesting that alphaB may be important in maintaining genomic stability.
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