Words similar to alpha-

Example sentences for: alpha-

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The human alpha-2C receptor is somewhat unique among the alpha-2 receptors in that it does not appear to undergo agonist-induced down-regulation [ 11 ] . The human alpha-2A adrenergic receptor, which does undergo down-regulation, has an acidic serine motif (EESSSSD) in the third intracellular loop.
By contrast, a deletion of twelve residues of the human alpha-2A receptor (293-304) which includes the EESSSSE motif did not appear to prevent agonist-induced down-regulation [ 26 ] . Thus a phosphorylation pathway may not be involved in agonist-induced down-regulation of the alpha-2A adrenergic receptor.
The human alpha-2C receptor, by contrast, has a DESSAAAE sequence in the same region [Figure 2; [ 22 ] ]. Thus, it is possible that the lack of desensitization and perhaps also down-regulation of the human alpha-2C receptor is due to the fact that there are only two hydroxyl residues in the DESSAAAE motif rather than the four hydroxyl residues in the alpha-2A EESSSSD motif.
Those metabolites could very possibly be water-soluble products, such as alpha-CEHC or gamma-CEHC that were not measured in this investigation.
113 nM) and similar to the previously reported K d of 0.056 nM for the wild-type alpha-2 receptor for [ 3H]rauwolscine in NaPO 4 buffer [ 23 ] . Inhibition experiments with [ 3H]rauwolscine indicated that the affinity of norepinephrine for the mutated receptors was approximately two-fold higher (lower K d value) than for wild-type receptor (Figure 3).