Example sentences for: allelic

How can you use “allelic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 2) have also been shown to be mutated in head and neck cancer [ 4 13 ] . Nevertheless, the large number of additional chromosomal regions with high frequencies of allelic loss in head and neck cancer strongly suggests that many suppressor genes still remain to be identified.

  • Likewise, Arabidopsis PAI2 and PAI3 genes that have been trans-methylated by the PAI1/PAI4 locus do not transfer their methylation status to naive singlet genes [ 12 ] . In fact, there are few well-documented cases for the non-allelic relay of trans-silencing ability [ 11 24 ] . Does this amount to an operational difference between allelic (paramutation) and non-allelic (trans-silencing) interactions, or does it simply reflect a lack of data?

  • This was indicated by the observation that allelic [ 6] mutations of a single gene ( Lps ) in mice could entirely abrogate the response to LPS, and did so with great specificity.

  • M6P/IGF2R allelic loss would therefore result in enhanced cellular bioavailability of this potent growth factor, thereby potentially increasing both cell proliferation and resistance to apoptosis [ 29 ] . The M6P/IGF2R also facilitates the activation of TGFβ, a potent cell growth inhibitor that is secreted in an inactive form (reviewed in [ 15 16 ] ). M6P/IGF2R mutation is therefore one mechanism by which cancer cells can become refractory to TGFβ's mitoinhibitory effect.

  • The Cars gene is not functionally imprinted, and the Nap1l4 gene shows a weak expression bias in some mouse tissues, but not in several human tissues examined to date [ 4 5 ] . The Obph1 gene, which shows a strong allelic bias in mRNA expression in the placenta, but not in other tissues, is located upstream of Tnfrh1 . Since assessment of allelic bias in the placenta is complicated by the presence of maternal cells, it is not known with certainty whether Obph1 is imprinted.


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