Example sentences for: allelic

How can you use “allelic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Thus, patients with a non-mutated M6P/IGF2R who received RT alone had the same long-term outcome as the overall population of patients who received RT and concurrent chemotherapy [ 31 ] . This implies that M6P/IGF2R allelic loss may help to identify a group of head and neck cancer patients who can be adequately treated with RT alone without exposure to the added morbidity of combined modality therapy.

  • A computational technique termed comparative genomic microarray analysis (CGMA) has previously been used to identify regions of allelic imbalance indirectly from gene-expression profiles of human tumors [ 8].

  • Realizing that loss on 18p is only one part of the complex genetic profile for breast cancer, we sought to discover whether genetic alteration on this chromosome correlated with LOH in other regions known to undergo allelic deletion in cancer.

  • The increased frequency of haplotype 1 in the Gambian sample has a profound impact on the allelic associations between SNPs as evaluated by chi-square test or as defined by the pairwise association efficiency parameter.

  • Entire lobules and large ducts of normal breast tissue can be derived from a single progenitor cell [ 47 ] , and LOH at various chromosomal locations is frequently detectable in morphologically normal lobules adjacent to breast tumors [ 48 ] . Lung tumors and head and neck tumors that develop in a localized region also often have a common clonal origin [ 3 4 49 ] . The high frequency of M6P/IGF2R loss of heterozygosity observed in the head and neck tumors in this study suggests that the phenomenon of "field cancerization", first described by Slaughter and his colleagues [ 2 ] in 1953, may in part result from the clonal proliferation of mucosal epithelial cells with M6P/IGF2R allelic loss.


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