Words similar to allele
Example sentences for: allele
How can you use “allele” in a sentence? Here are some example sentences to help you improve your vocabulary:
Collectively, these findings imply that the exon 20 T790M mutation was present on the same allele as the exon 21 L858R mutation, and that a subclone of cells harboring these mutations emerged during drug treatment.
Modulation of this mitogenic pathway occurs in part via the M6P/IGF2R, which functions in the internalization and degradation of IGF-II [ 10 ] . M6P/IGF2R is also important in activation of TGF-β, a potent growth inhibitor for most cell types, and in binding, transport and activation of lysosomal enzymes, such as cathepsins [ 12 13 ] . It has been shown that M6P/IGF2R expression is significantly reduced in both rat and human hepatocellular carcinomas [ 14 ] . Loss of hetorozygosity (LOH) at the M6P/IGF2 receptor gene locus on 6q26-27 coupled with somatic point mutations in the remaining allele has recently been demonstrated in liver and breast cancers [ 15 16 17 18 19 20 21 22 23 ] . In addition, somatic mutations of the M6P/IGF2R gene were also found in prostate cancer, lung carcinoma, and genetically unstable cancers of the endometrium, brain, stomach and colorectum [ 24 25 26 27 28 29 ] . The findings of LOH and mutations of M6P/IGF2R in a wide variety of tumor types have led to the proposition that the M6P/IGF2R is a tumor suppressor gene.
[ 10 ] also demonstrated that the T Wis allele of T results from the insertion of an endogenous retrovirus-like early transposon (ETn) element into the splice donor site of exon 7 of the 8 exon T locus.
We found that 3/26 Arg +Ura +segregants emanating from a CES1/ces1::UAU1 heterozygote were homozygous for disruption at both loci ( ces1::UAU1/ces1::URA3 ) and had lost the wild-type CES1/ZDS1 allele [B.
3 kb in this study) the SNP markers are poorly correlated: if a true disease-susceptibility allele existed in the TNF gene, many of the other SNPs would be inefficient markers of that disease allele.
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