Example sentences for: allele-specific

How can you use “allele-specific” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These two elements control, respectively, the allele-specific expression of the H19/Igf2/Ins2 gene cluster, and the second gene cluster containing Kcnq1, the antisense transcript Kcnq1ot1, p57 Kip 2/ Cdkn1c, Slc22a1l, Ipl/Tssc3 and possibly additional genes [ 1 2 ] . There is good evidence assigning one border of the overall imprinted region to the DNA immediately downstream of H19 [ 3 ] . However, the other border, which must lie upstream of Ipl is less well-defined [ 4 ] . Here we show evidence for weak imprinting of a gene, Tnfrh1 , which is located upstream of

  • The intuition behind our result that population heterozygote advantage need not reflect allele-specific overdominance can be seen in two simple examples.

  • We have shown that when allele-specific overdominance exists, it will often be manifest as population heterozygote advantage, but that a finding of population heterozygote advantage may be consistent with other patterns of allele-specific effects; for example, when resistant and susceptible alleles are equally common and equally diverse, population heterozygote advantage will occur if allele-specific effects are additive, dominant or overdominant.

  • Figure 1shows that allele-specific overdominance (the biological phenomenon of interest) and population heterozygote advantage (the finding of epidemiological studies such as those cited above) are two different things.

  • The method was also simplified so that instead of one tube each for the two allele-specific OCPs, a single-tube for both OCPs was used.


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