Example sentences for: allele-specific

How can you use “allele-specific” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Moreover, direct estimates of the allele-specific effects of heterozygosity (relative to the corresponding homozygotes), nearly absent in the infectious disease-HLA literature, are frequently found in studies of HLA genotype and chronic (mostly autoimmune) diseases [ 28 29 30 ] . We do not know the reason for this difference in approach, but suspect that some infectious disease investigators, informed by the evolutionary hypothesis of overdominance for infectious disease resistance and by animal studies, may have a special interest in detecting effects of heterozygosity per se . Many studies of HLA-autoimmune disease associations, on the other hand, seem to focus more on the effects of individual alleles and, having established these, move on to investigate the dependence of these effects on genetic modifiers, including the identity of the individual's other allele at the same locus.

  • As was true of the BL/6 × CAST crosses, the parent-of-origin dependence of the allele-specific expression was superimposed on a baseline bias towards hyper-expression of the BL/6 allele.

  • We have shown that when allele-specific overdominance exists, it will often be manifest as population heterozygote advantage, but that a finding of population heterozygote advantage may be consistent with other patterns of allele-specific effects; for example, when resistant and susceptible alleles are equally common and equally diverse, population heterozygote advantage will occur if allele-specific effects are additive, dominant or overdominant.

  • Quantitation of allele-specific FBN1transcripts

  • The intuition behind our result that population heterozygote advantage need not reflect allele-specific overdominance can be seen in two simple examples.


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