Words similar to allele-specific
Example sentences for: allele-specific
How can you use “allele-specific” in a sentence? Here are some example sentences to help you improve your vocabulary:
In this report, we show that although population heterozygote advantage is compatible with allele-specific overdominance, it is also compatible with the opposite; i.e., population heterozygote advantage could arise in a population in which every heterozygote had a worse disease outcome than either of the corresponding homozygotes ("allele-specific underdominance").
Figure 1shows that allele-specific overdominance (the biological phenomenon of interest) and population heterozygote advantage (the finding of epidemiological studies such as those cited above) are two different things.
The annealing/ ligation reaction therefore included both of the allele-specific OCPs (OCP-1822C and OCP-1822T, Table I), and the ERCA reaction was performed in the presence of both of the allele-specific P2 Amplifluor primers (P2-1822C-TET and P2-1822T-FAM).
Although population heterozygote advantage and allele-specific overdominance are different [ 10 ] , reports of population heterozygote advantage have frequently been interpreted as confirmations of the Doherty-Zinkernagel hypothesis of allele-specific overdominance.
As noted by Doherty and Zinkernagel [ 4 ] , simple dominance for resistance to each of several diseases can create allele-specific overdominance for total fitness, if different alleles confer resistance to different diseases [ 10 31 ] . For these reasons, our results, while relevant to the longstanding debate over the relative importance of various kinds of balancing selection in maintaining MHC diversity [ 32 ] , raise doubts about only one of several lines of evidence for the overdominance hypothesis.
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