Example sentences for: allele-specific

How can you use “allele-specific” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Although neither population heterozygote advantage nor allele-specific overdominance implies the other, the two phenomena are of course related.

  • Illustrating that allele-specific cis -acting sequences must dictate TAS-position use, alleles differ at most TAS positions: only 3 are used by all alleles; 24 positions (†-marked) are used by more than one, but not all alleles, and 19 positions (*-marked) are used by only one allele.

  • Moreover, direct estimates of the allele-specific effects of heterozygosity (relative to the corresponding homozygotes), nearly absent in the infectious disease-HLA literature, are frequently found in studies of HLA genotype and chronic (mostly autoimmune) diseases [ 28 29 30 ] . We do not know the reason for this difference in approach, but suspect that some infectious disease investigators, informed by the evolutionary hypothesis of overdominance for infectious disease resistance and by animal studies, may have a special interest in detecting effects of heterozygosity per se . Many studies of HLA-autoimmune disease associations, on the other hand, seem to focus more on the effects of individual alleles and, having established these, move on to investigate the dependence of these effects on genetic modifiers, including the identity of the individual's other allele at the same locus.

  • The annealing/ ligation reaction therefore included both of the allele-specific OCPs (OCP-1822C and OCP-1822T, Table I), and the ERCA reaction was performed in the presence of both of the allele-specific P2 Amplifluor primers (P2-1822C-TET and P2-1822T-FAM).

  • As we have suggested above, it is biologically and epidemiologically useful to determine (a) the beneficial or harmful effects of specific alleles, and (b) the effects of heterozygosity, such as allele-specific overdominance; we show here that unconditional comparisons of all heterozygotes to all homozygotes can reflect either or both of these, and cannot distinguish them.


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