Example sentences for: alignment-based

How can you use “alignment-based” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • With the complete genome sequences at hand, it appears natural to seek for alternatives to traditional, alignment-based tree-building in the form of integral characteristics of the evolutionary process.

  • Previously annotated gene structures that disagreed with the cDNAs were replaced by the cDNA alignment-based gene models, and new gene models were created where pre-existing gene annotations were lacking.

  • Multiple alignment-based secondary-structure prediction of the Bro-N domain reveals a core with two head-to-tail units of a β-hairpin followed by an α-helix (Figure 3).

  • The hybrid-fold-recognition method, which combines sequence-profile analysis with alignment-based secondary-structure prediction [ 22] and the 3D-PSSM method [ 23] both suggested a likely α-amylase-like triosephosphate isomerase (TIM) barrel structure for this protein family.

  • The results of the present study suggest that genome trees based on new, integral criteria do not provide substantial advantages in phylogenetic reconstruction over more traditional, alignment-based methods expanded to the genomic scale.


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