Example sentences for: adp-ribosylation

How can you use “adp-ribosylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Electroporation of C3 induces complete ADP-ribosylation of Rho in HPB-ALL

  • In the present study, we demonstrate that ADP-ribosylation of the GTPase Rho in HPB-ALL cells does not result in a decrease in constitutively high adhesion to the extracellular matrix component fibronectin.

  • Previous reports have demonstrated that ADP-ribosylation of B-lymphoid cell lines by C3 treatment inhibits phorbol ester induced cellular homotypic aggregation [ 18 ] . Also, phorbol ester and chemoattractant (IL-8 and fMLP) induced pre-B lymphoblastoid adhesion to VCAM-1 and neutrophil adhesion to fibrinogen was abrogated in a dose-dependent manner by C3 exoenzyme [ 36 ] . This may indicate that in cells of hematopoietic lineages, the induction of an increased adhesive state may be susceptible to regulation by Rho proteins.

  • The involvement of Rho GTPases in regulating integrin dependent events such as leukocyte homotypic aggregation and in chemokine upregulation of integrin-mediated adhesion has recently been identified [ 18 19 ] . ADP-ribosylation of Rho in neutrophils by treatment with C3 not only inhibits cellular locomotion, but augments chemoattractant induced actin polymerization [ 20 21 ] . Moreover, inactivation of Rho in monocytic cells leads to accelerated formation of filopodia, and it has been proposed that Rho is a negative regulator of actin polymerization within this cell type [ 22 ] . Active Rho is also required for normal morphology, motility, and cytolytic activity of IL-2 activated NK cells [ 23 24 ] . We and others have demonstrated the importance of Rho in T lymphocyte activation [ 25 26 ] . Given the role played by Rho in the regulation of actin microfilaments in other cell types, and the indispensability of a functional actin cytoskeleton in lymphocyte motility and activation, it is of importance to study Rho's role in the regulation of T lymphocyte integrin function and maintenance of cytoskeletal organization.

  • This small member of the Ras GTPase superfamily has been implicated in fibroblast models of integrin dependent actin stress fiber formation, focal contact assembly [ 13 ] , and gene induction via the serum response element [ 14 ] . Studies of Rho function have been facilitated by the use of specific toxins such as Clostridium botulinum toxin C3 which catalyses the ADP-ribosylation and inactivation of Rho [ 15 16 17 ] . The function of this GTPase and related family members such as Rac and Cdc42 has been extensively studied in the fibroblast model.


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