Words similar to adp-ribosylation
Example sentences for: adp-ribosylation
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Similar observations were obtained for other gene clusters, including amylases on 1p21, annexins on 4q21, homeobox proteins on 7p15 and 17q21, metallothioneins on 16q13, crystalline proteins on 2q33, glutathione- S -transferases (m1, m2, m3, m4 and m5) on 1p13, histone families (H2A/H2B/H3/H4) on 6p21, killer cell lectin-like receptors on 12p13, proline-rich proteins on 12p13, protocadherins on 5p15, s100 calcium-binding proteins on 1q21, keratins on 17q12, ADP-ribosylation factors (3, 4 and 5) on 10q22, and the major histocompatibility complex on 6p21.
ADP-ribosylation of Rho proteins by C3 exoenzyme prevents neurite retraction in the specialized growth cone of developing neurons, and in fact promotes neurite outgrowth in the same fashion as microinjection of purified dominant negative RhoA T19N [ 39 ] . In these instances, neuronal N1E-115 cell outgrowth induced by inactivation of RhoA was mimicked by microinjection of Rac1- or Cdc42-GST fusion proteins, and could be abolished by coinjection of dominant negative Cdc42 T17Nor Rac1 T17N [ 39 ] . From these results, the authors concluded that inactivation of RhoA by C3 exoenzyme treatment resulted in the activation of Rac1 and Cdc42 GTPases, suggesting the mutually exclusive function of RhoA and Rac1/Cdc42.
DGW drafted the manuscript, performed ADP-ribosylation experiments, adhesion and spreading assays, and immunofluorescence.
The phenotype induced by ADP-ribosylation of Rho in T lymphocytes appeared different than that induced in fibroblast models, where microinjection of C3 results in fibroblast retraction of pseudopodia, with the cell body rounding up eventually to become non-adherent [ 17 ] . Video time-lapse microscopy demonstrated the elongation of aberrant pseudopods in HPB-ALL cells plated on the β1 substrate VCAM-1, rather than an altered retraction of already formed pseudopods.
Electroporation of C3 induces complete ADP-ribosylation of Rho in HPB-ALL
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