Example sentences for: adp-ribosylation

How can you use “adp-ribosylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Previous reports have demonstrated that ADP-ribosylation of B-lymphoid cell lines by C3 treatment inhibits phorbol ester induced cellular homotypic aggregation [ 18 ] . Also, phorbol ester and chemoattractant (IL-8 and fMLP) induced pre-B lymphoblastoid adhesion to VCAM-1 and neutrophil adhesion to fibrinogen was abrogated in a dose-dependent manner by C3 exoenzyme [ 36 ] . This may indicate that in cells of hematopoietic lineages, the induction of an increased adhesive state may be susceptible to regulation by Rho proteins.

  • Although ADP-ribosylation of Rho does not significantly alter the subcellular distribution of RhoA, Rho activity is inhibited.

  • In the present study, we demonstrate that ADP-ribosylation of the GTPase Rho in HPB-ALL cells does not result in a decrease in constitutively high adhesion to the extracellular matrix component fibronectin.

  • This small member of the Ras GTPase superfamily has been implicated in fibroblast models of integrin dependent actin stress fiber formation, focal contact assembly [ 13 ] , and gene induction via the serum response element [ 14 ] . Studies of Rho function have been facilitated by the use of specific toxins such as Clostridium botulinum toxin C3 which catalyses the ADP-ribosylation and inactivation of Rho [ 15 16 17 ] . The function of this GTPase and related family members such as Rac and Cdc42 has been extensively studied in the fibroblast model.

  • Similar observations were obtained for other gene clusters, including amylases on 1p21, annexins on 4q21, homeobox proteins on 7p15 and 17q21, metallothioneins on 16q13, crystalline proteins on 2q33, glutathione- S -transferases (m1, m2, m3, m4 and m5) on 1p13, histone families (H2A/H2B/H3/H4) on 6p21, killer cell lectin-like receptors on 12p13, proline-rich proteins on 12p13, protocadherins on 5p15, s100 calcium-binding proteins on 1q21, keratins on 17q12, ADP-ribosylation factors (3, 4 and 5) on 10q22, and the major histocompatibility complex on 6p21.


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