Words similar to adpase

Example sentences for: adpase

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E174 in ACR3 and S218 in ACR4 are required for catalytic function [ 12 ] . Substitution of H59 in ACR1 converted CD39 into an ADPase in a quaternary structure dependent manner [ 13 ] . Mutation of W187A in ACR3 affected CD39 folding and translocation, while mutation of W459A in ACR5 increased ATPase activity but diminished ADPase activity [ 14 ] . Mutations of D62 and G64 of ACR1 and D219 and G221 of ACR4 demonstrated that the nucleotide phosphate binding domains of NTPDases are similar to those present in the actin/heat shock protein/sugar kinase superfamily [ 15 ] . These results suggest that the conserved residues of the ACR1 to 5 regions are involved in the catalytic mechanism of CD39.
The changes of D62 on ACR1, E174 on ACR3, D213 (D219 in HB6) and S218 on ACR4 dramatically decrease both ATPase and ADPase activities of CD39 [ 12 15 ] . Figure 7summarizes the possible coordination of Ca 2+from the data of species T, species D1, and species D2 in the different situations of sCD39 catalysis.
Ecto-Nucleoside triphosphate diphosphohydrolases (E-NTPDases, formerly called ecto-ATPases) hydrolyze nucleotides in the presence of divalent cations and are insensitive to inhibitors of P-type, F-type, and V-type ATPases [ 1 ] . Three isoforms that differ in the ratio of ATPase/ADPase activity are present on the cell surface [ 2 ] : E-NTPDase1 with a ratio of 1, E-NTPDase2 with a ratio of 10 and E-NTPDase3 with a ratio of 3-5.