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Example sentences for: acth

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LIF and LIFR are functionally expressed in rodent tissues that are central to GC production: the hypothalamus [ 8 ] and pituitary [ 9 10 11 12 ] . LIF works in synergy with corticotropin-releasing hormone (CRH) in the hypothalamus to increase pituitary pro-opiomelanocortin (POMC) and, ultimately, pituitary adrenocorticotrophin hormone (ACTH) [ 9 11 13 14 15 16 ] . LIF also stimulates POMC gene expression directly in the pituitary [ 9 11 15 17 ] . LIF up-regulates pituitary prohormone convertase (PC1).
A comparison of mortality rates for basal cortisol and cortisol responses to ACTH in both groups is shown in Figure 1. The median time to death was 5 days (95% CI 2.55-8.
The strongest ACTH immunolabeling was seen in the pars intermedia of the anterior pituitary with scattered labeling in the pars distalis.
AI = adrenal insufficiency; APACHE = Acute Physiology and Chronic Health Evaluation; ACTH = corticotropin; CI = confidence interval; OR = odds ratio; SOFA = Sequential Organ Failure Assessment.
Increased pituitary ACTH indicates that, in the absence of LIFR, pituitary ACTH could still be induced.