Words similar to abrogated
Example sentences for: abrogated
How can you use “abrogated” in a sentence? Here are some example sentences to help you improve your vocabulary:
RNA interference (RNAi), mediated by short interfering double-stranded RNA molecules (siRNA or dsRNA), is now recognized as a major mechanism of post-transcriptional gene silencing (PTGS) in essentially all eukaryotes [ 16 ] . Recently, the technique has been successfully applied to cultured mammalian cells, whereby introduction of 21-nucleotide long synthetic dsRNA molecules corresponding to specific mRNA sequences effectively and specifically degraded the cognate mRNAs and abrogated the expression of the corresponding proteins [ 17 18 ] . This prompted us to test a similar approach to knockdown PfPP1 function in the erythrocytic P. falciparum stages.
It has been shown that overexpression of a region of this protein encompassing the GOLD domain caused disassembly of the Golgi structure and abrogated protein transport from the ER to the Golgi [ 16].
In syk -deficient DT40 cells, BCR induced apoptosis was abrogated indicating that Syk was necessary for this cellular response [ 38 ] . Having established cells with constitutive Syk activity, it was now possible to establish if Syk activation is sufficient for any of the signaling responses.
Actin filament elongation would continue and RhoA dependent retraction of filamentous actin would be abrogated.
These signaling events are generally not entirely abrogated and kinetic analyses have revealed that the sustained phases are particularly impaired in the absence of Btk [ 8, 9, 13].
Loading...