Example sentences for: abrogated

How can you use “abrogated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • RNA interference (RNAi), mediated by short interfering double-stranded RNA molecules (siRNA or dsRNA), is now recognized as a major mechanism of post-transcriptional gene silencing (PTGS) in essentially all eukaryotes [ 16 ] . Recently, the technique has been successfully applied to cultured mammalian cells, whereby introduction of 21-nucleotide long synthetic dsRNA molecules corresponding to specific mRNA sequences effectively and specifically degraded the cognate mRNAs and abrogated the expression of the corresponding proteins [ 17 18 ] . This prompted us to test a similar approach to knockdown PfPP1 function in the erythrocytic P. falciparum stages.

  • It has been shown that overexpression of a region of this protein encompassing the GOLD domain caused disassembly of the Golgi structure and abrogated protein transport from the ER to the Golgi [ 16].

  • In syk -deficient DT40 cells, BCR induced apoptosis was abrogated indicating that Syk was necessary for this cellular response [ 38 ] . Having established cells with constitutive Syk activity, it was now possible to establish if Syk activation is sufficient for any of the signaling responses.

  • Actin filament elongation would continue and RhoA dependent retraction of filamentous actin would be abrogated.

  • These signaling events are generally not entirely abrogated and kinetic analyses have revealed that the sustained phases are particularly impaired in the absence of Btk [ 8, 9, 13].


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