Example sentences for: abrogate

How can you use “abrogate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This was indicated by the observation that allelic [ 6] mutations of a single gene ( Lps ) in mice could entirely abrogate the response to LPS, and did so with great specificity.

  • We have recently reported the role of the inhibitor of NF-κB (IκB) family member Bcl-3 in IL-1-induced MMP-1 expression [ 24 ] . Here we show that overexpression of Bcl-3 can partly abrogate CDDO's inhibitory effects on MMP-1 in SW-1353 cells, suggesting that Bcl-3 might be a target for CDDO.

  • The specificity of dsRNA activity was further tested by using a dsRNA against cellular lamin A/C that was earlier shown to specifically abrogate lamin A/C synthesis in a variety of cultured cell lines [ 2 ] . As shown in Fig.

  • Consistent with this, the T790M mutation has been shown not to abrogate the catalytic activity of wild-type EGFR [22].

  • Properly designed synthetic 21-nucleotide long double-stranded RNA (dsRNA) molecules can effectively and specifically abrogate translation of target RNAs without activating a general interferon response.


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