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Example sentences for: zn-ribbon

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It also has high affinity for binding to single-stranded DNA on its own when separated from the three tetracysteine motifs [ 36 ] . Based on the structural and DNA-binding properties of the E. coli topoisomerase I 14 kDa domain, one can conclude that it is possible for a subdomain in topoisomerase I to lose the Zn(II) binding cysteines during evolution and still maintains the Zn-ribbon structure and single-strand DNA binding properties [ 7 ] .
Consistent with this, the Zn-ribbon had been subsequently reused in several basal archaeo-eukaryotic transcription factors, such as TFIIB, TFIIE and TFIIS [ 67 68 71 72 73 ] .
Although the sequences of the Zn-ribbons of bacterial and archaeo-eukaryotic DDRP subunits have diverged considerably, their similar location in the orthologous polypeptides from different kingdoms suggests that β' subunit of LUCA already contained a Zn-ribbon.
The BBM1 domain is inserted after the Zn-ribbon in all bacterial β' subunits and, additionally, into the SBHM domain of the β subunit in proteobacteria, Aquifex and chlamydiae (Fig.
Additionally, the Zn-ribbon underwent duplication and elaboration in the β' subunit and was also recruited in various transcription factors.