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Example sentences for: zn-ribbon

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It also has high affinity for binding to single-stranded DNA on its own when separated from the three tetracysteine motifs [ 36 ] . Based on the structural and DNA-binding properties of the E. coli topoisomerase I 14 kDa domain, one can conclude that it is possible for a subdomain in topoisomerase I to lose the Zn(II) binding cysteines during evolution and still maintains the Zn-ribbon structure and single-strand DNA binding properties [ 7 ] .
Additionally, the Zn-ribbon underwent duplication and elaboration in the β' subunit and was also recruited in various transcription factors.
Based on the crystal structure, it has been proposed that the region containing the Zn ribbon may interact with the promoter during transcription initiation in bacteria [ 23 ] . Hence, it is plausible that a nucleic-acid-binding Zn-ribbon had been recruited to the ancestral polymerase core, which consisted of the DPBB domains, and contributed to non-specific interactions with the template.
Although the sequences of the Zn-ribbons of bacterial and archaeo-eukaryotic DDRP subunits have diverged considerably, their similar location in the orthologous polypeptides from different kingdoms suggests that β' subunit of LUCA already contained a Zn-ribbon.
4), ii) the Zn-ribbon, which was probably involved in interactions with the template, and iii) the SBHM domain that stabilized the interactions between the DPBB domains forming the catalytic cleft (Fig.