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Example sentences for: yrhs

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Closely spaced acidic residues that coordinate divalent cations are characteristic of the active sites of most nucleic acid polymerases, in spite of the fact that they belong to several unrelated structural folds [ 9 13 14 17 28 29 59 ] . Given that the DbDGD motif is the only set of closely spaced acidic residues shared by the RDRPs and the YRHs, it is likely to form part of the nucleotidyltransferase active site of these enzymes.
The multiple-alignment-based secondary structure prediction for the RDRPs and the YRHs indicated that, like the similar region of the β' subunit, this region was enriched in β-strands (Fig.
Taken together, all these observations point to a scenario for the origin of the RDRP, under which the RDRPs and the YRHs diverged from the DDRPs at a stage of evolution that succeeded the divergence of the DPBB domains of the β and β' subunits (Fig.
The Gibbs sampling alignment procedure detected 9 statistically significant motifs that are conserved across the entire set of RdRps and YRHs, with a probability of occurrence by chance in this set of protein sequences estimated as <10 -18.
Secondary structure prediction, which was produced using the multiple alignment as the query, included 16 α-helices and 20 β-strands, which are conserved in RDRPs and YRHs (Fig.