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Example sentences for: yrh

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The eukaryotic RDRP is part of a large ensemble of functionally linked proteins, which include the Dicer helicase-nuclease, PIWI family proteins, the Hen-2/Corymbosa-like RNA methylase, AlkB-related RNA demethylases, and Lin28-like RNA-binding proteins [ 1 45 46 ] . Since no closely related homologs of any of these proteins are encoded in the genomes of the phages that encode YRH proteins, the latter are unlikely to function in a biological context similar to that of the eukaryotic RDRPs.
Interestingly, the PSI-BLAST searches started with the sequences of the RDRP module of the RDRPs and the YRH proteins consistently retrieved the β' subunits of DDRPs, albeit at statistically not significant E-values.
Thus, these comparisons identify previously undetected prokaryotic homologs of the eukaryotic RDRPs, the YRH proteins, which probably also have RNA-dependent RNA polymerase activity.
Eukaryotes might have acquired the YRH gene from a bacteriophage at an early stage of their evolution and retained the RDRPs thanks to the selective advantage conferred by the new level of gene expression regulation mediated, in part, by these enzymes.
Possible functions of the YRH proteins include a regulatory activity via amplification of antisense RNAs or perhaps a more conventional role as a DNA-dependent RNA polymerase of the respective phages.