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All the exons of the gene (Figure 1A) were successfully amplified by PCR in all 10 controls and all 40 patients with 46,XX spontaneous premature ovarian failure.
We thought we could ignore the error and it would go away, but readers keep reminding us of what might be called, because of its prominence, a typogiraffical error: in Murdering the Language [OBITER DICTA, XX,4,5], the grammatically proper form would have been Omar m'a tuée, (reflecting the feminine gender of the preceding m ') and not, as printed, tué .
--Dante Alighieri, The Inferno (Canto XX, Circle Eight--The Fortune Tellers and Diviners), early 14 th century
Normal karyotype and normal fluorescent in-situ hybridization (FISH) for the elastin gene locus on chromosome 7 (46, XX, negative ELN 7q11.
A second, distinct but compatible hypothesis was suggested by Doherty and Zinkernagel soon after their discovery of MHC restriction: since each MHC allele provides an infected individual with the ability to present a particular set of antigens, individuals who are heterozygous (say, genotype XY) at a particular MHC locus may mount a more vigorous immune response to a given infection, resulting in a better outcome, than individuals who are homozygous for either of the corresponding alleles (XX or YY) [ 4 ] .