Example sentences for: whr
How can you use “whr” in a sentence? Here are some example sentences to help you improve your vocabulary:
BMI = body mass index; LRT = likelihood ratio test; SHBG = sex hormone binding globulin; WHR = waist-hip ratio.
In contrast, the Iowa Women's Health Study showed no association with WHR, and an earlier report of interaction with family history appeared to have attenuated with time [ 25 26 ] . In the New York University Women's Health Study, the multivariable analysis showed an association between the lowest quintile and the highest quintile of WHR and breast cancer of 1.72 (95% confidence interval = 1.0-3.
The WHR, a measure of central adiposity, is gaining increased use as a measure of etiologically significant obesity and is thought to be more closely related to pathology, especially coronary heart disease, diabetes mellitus and stroke [ 7 ] . The metabolic changes that accompany obesity include peripheral hyperinsulinemia, hyperglycemia and glucose intolerance, hypertriglyceridemia, decreased serum low-density lipoprotein, increased serum very low-density lipoprotein, increased serum leptin, dyslipidemia, increased serum cortisol clearance, increased serum C-peptide level, downregulation of insulin receptors and an exaggerated insulin response to an oral glucose load [ 12 13 14 15 ] . These changes, especially when they occur in early adulthood, may be of fundamental importance in the development of breast cancer [ 9 16 ] .
Most case-control studies have found an association between WHR and the risk of postmenopausal breast cancer [ 28 29 30 31 32 33 34 35 36 37 ] , and most report either null or weakly positive association with premenopausal breast cancer.
In multivariable logistic regression analysis, adjusted for age and height, there was a significant association between the highest tertile of WHR and breast cancer risk (LRT P = 0.10; Table 6).
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