Words similar to voltage-sensitive

Example sentences for: voltage-sensitive

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Overall, these data are consistent with previous reports that endocrine cells express voltage-sensitive ion channels that can contribute to the regulation of not only resting membrane potential and cell volume, but also cell proliferation and steroidogenesis [ 12 13 16 18 21 28 29 30 31 32 33 34 35 36 37 ] . The K +currents blocked by 4-AP in pig GC are conducted by ion channels formed by heteromeric complexes of pore-forming subunits from the KCNA (also called Kv1 or Shaker) family of proteins and accessory subunits from the KCNAB (also called Kvβ) family of proteins [ 4 ] . Similar 4-AP-sensitive K +currents play a key role in transduction of mitogenic signals in a variety of cell types, and 4-AP treatment has been associated with not only growth arrest but also apoptosis [ 2 3 8 9 10 14 38 39 40 41 42 ] .
The initial MTX-induced increase in [Ca 2+] i reflects the activation of a Ca 2+-permeable non-selective cation channel (CaNSC) [ 1 4 5 6 7 8 ] . This channel, which has a reported conductance in the range of 12-40 pS depending on ionic conditions [ 5 9 10 11 ] , causes rapid membrane depolarization, which in excitable cells, leads to activation of voltage-sensitive channels.
The effects of 4-AP in serum-supplemented GC cultures are consistent with previous reports that antagonism of voltage-sensitive K +currents can modulate basal and gonadotropin-stimulated progesterone accumulation in the absence of any effect on cell growth or death.