Words similar to voltage-gated
Example sentences for: voltage-gated
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Earlier studies in the voltage-gated Na +channel had shown that pore function was not compromised when the II-III linker or III-IV linker was cut and the two fragments were coexpressed each in a separate vector [ 37 ] . We would thus conclude that in the case of the Ca 2+channel, an intact II-III loop is essential for this function since neither fs-α 1S nor the combined expression of the two truncated fragments (not shown) was able to rescue Ca 2+current.
Protein-protein complementation between the N-terminal and C-terminal fragments produced a DHPR capable of functioning as EC coupling voltage sensor, thus suggesting the presence of at least two functional modules within α 1S . Recent evidence suggests that the four internal repeats of the voltage-gated Na +channel, which is closely related to the L-type Ca 2+channel encoded by the DHPR, have non-equivalent functional roles because the S4 segments of repeats I and II move much faster than those of repeats III and IV [ 40 ] . By analogy, the "fast-moving" module of the DHPR would be represented by the N-terminal fragment and the "slower-moving" module by the C-terminal fragment.
Tetraethylammonium is known as a pore-occluding blocker of voltage-gated potassium channels [ 1 ] , but it also blocks other cationic channels such as calcium-dependent K +channels [ 2 3 ] and the nicotinic acetylcholine receptor [ 4 ] . TEA at 0.1 to 10 mM also inhibits osmotic water flux through human AQP1 channels expressed in Xenopus oocytes, decreasing the net swelling rate in hypotonic saline by 30-40% as compared to AQP1-expressing oocytes not treated with TEA [ 5 ] . This blocking effect on osmotic water flux was demonstrated to involve AQP1 channels specifically by using site-directed mutagenesis (tyrosine 186 to phenylalanine) to generate a Y186F AQP1 channel that is insensitive to block by TEA, but retains sensitivity to block by mercury.
To measure DHPR charge movements and to separate these charge movements from those produced by other voltage-gated channels, a) ionic currents were blocked; b) the linear component of the cell capacity was subtracted using a P/4 procedure and by analog compensation; and c) we used a pulse protocol that eliminated the immobilization-sensitive charge movements from voltage-gated Na +channels and presumably also from T-type Ca 2+channels.
Like the Kv3 ( Shaw ) family, KQT (KCNQ) K +-channel genes are more abundant in Anopheles than in Drosophila . Sequence analysis suggests these channels evolved before other classical voltage-gated K +channels (Kv1-K4).
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