Words similar to voltage-sensing

Example sentences for: voltage-sensing

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The dihydropyridine receptor (DHPR) of skeletal muscle consists of α 1S , α 2 , β 1a and γ 1 subunits [ 1 ] . The α 1 subunit is a large four-repeat transmembrane protein of ~220 KDa that contains the basic functional elements of the L-type Ca 2+channel, including the Ca 2+selective pore and S4 "voltage-sensing" transmembrane segments in each of the four internal repeats [ 2 ] . β subunits are ~65 kDa cytosolic proteins essential for membrane trafficking, modulation of channel kinetics, and for excitation-contraction (EC) coupling [ 3 4 ] . The α 2 subunit is a highly glycosylated ~175 kDa protein formed by two disulfide-linked peptides [ 5 ] , whereas the γ 1 subunit is a ~32 kDa skeletal muscle-specific protein of four presumptive transmembrane domains with almost unknown function [ 6 7 ] .