Words similar to virulent
Example sentences for: virulent
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The microarray data for the response to 1 hour of ozone treatment and five days after virulent oomycete infection
I have demonstrated that a gene coding for a bifunctional catalase-peroxidase is likely a transfer from archaea to a variety of pathogenic bacteria, including E. coli O157:H7 [ 9 ] . Although not yet directly implicated in O157:H7 as a virulence factor, this enzyme has been implicated as a virulence factor in Mycobacterium tuberculosis [ 24 26 ] , and in Legionella pneumophila [ 25 ] . Furthermore, this E. coli O157:H7 catalase-peroxidase has been associated with enterohaemorrhagic hemolysin in a variety of shiga-like toxin-producing (verotoxin-producing) E. coli [ 30 31 ] . This correlation of the presence of the catalase-peroxidase in many virulent but not in avirulent strains suggests a direct role in the virulence of enterohemorrhagic E. coli .
The H-box factor (HBF) motif was over-represented in the promoters of genes represented in the virulent bacterial library, heat-shock element (HSE) and Myb4 motifs were over-represented in the avirulent bacterial library, and the Myc motif was over-represented in the SA library (Table 3b).
In this study we have further characterized the sagA/pel mutant of isolate CS101 and report that it is less virulent than the wild type organism.
The precise biological role of SLS in streptococcal infections remains controversial [ 7 ] . The original analysis of the sagA gene demonstrated that inactivation of the gene encoding the polypeptide component of SLS rendered the organism less virulent in a dermonecrotic mouse model [ 3 ] . In a related series of studies, Li et al also isolated a mutant that not only lacked SLS activity but also affected other phenotypes [ 4 ] . The additional phenotypes included surface M and M-related protein as well as the secreted cysteine protease, streptococcal pyrogenic exotoxin B, SpeB [ 4 ] . The disrupted gene was termed pel (pleotrophic effect locus).
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