Words similar to virucidal
Example sentences for: virucidal
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Comparative virucidal activity of polymeric anionic microbicide candidates
In order to contribute to the understanding of the potential virucidal activity of anionic polymers, their capacity to induce gp41 six-helix bundle formation was measured and compared with that of CAP in soluble form (pH 7.0).
For the selection of the most promising candidate microbicides, it is important to compare not only their virus inhibitory and virucidal activities, but to also study their potential untoward effects.
Such activity was reported for dextran sulfate after 2 h incubation with HIV-1 [ 2 ] but results of other studies indicated that dextran sulfate failed to neutralize virus infectivity [ 4 10 ] . Inactivation of HIV-1 by carrageenan was reported in a review article [ 18 ] . BufferGel is virucidal against HIV-1 by providing a buffered low pH environment (pH 3.9 [ 25 ] ), but virus inactivation might be incomplete and possibly compromised by minor pH increases due to the presence of seminal fluid [ 40 ] . To be effective in preventing infection by direct virus inactivation, anti-HIV-1 microbicides must be virucidal against both X4 and R5 viruses, utilizing CXCR4 and CCR5 as coreceptors [ 39 41 ] , respectively, R5 HIV-1 being most frequently sexually transmitted.
To overcome this problem, CAP in a micronized form was used and proven to have virucidal activity against HIV-1 IIIB [ 31 ] and shown to be effective in reducing vaginal infection by simian immunodeficiency virus (SIV) in a macaque model [ 34 ] . Micronized CAP provides a low pH buffering system and this may have contributed to its virucidal properties.
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