Example sentences for: vegf-a

How can you use “vegf-a” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It was recently reported that continuous delivery of VEGF-A into murine hearts by retroviral transfer led to the formation of aberrant vessels and hemangioma-like structures [ 23].

  • The VEGF-A family of polypeptides consists of a number of biochemically distinct isoforms (three isoforms in the mouse and up to five in humans) that are generated through alternative mRNA splicing of a single gene [ 4, 5].

  • Subsequent studies have revealed that VEGF-A administration causes greater vasodilatation of coronary vessels than serotonin or nitroglycerin, and also causes tachyphylaxis via a nitric oxide-dependent mechanism [ 39].

  • If VEGF-A delivery leads to significant circulating levels, as has been observed following myocardial transfection with VEGF-A cDNA [ 31], then it may possibly affect angiogenesis elsewhere [ 32].

  • Finally, since multiple VEGF-A isoforms are expressed during vascular development [ 42], it will also be important to determine whether the use of multiple isoforms in angiogenesis therapy will be necessary to replicate in vivo conditions.


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