Words similar to vegf
Example sentences for: vegf
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Tie1 is an orphan receptor, whereas the ligands of Tie2 receptor have been identified as angiopoietin (Ang)-1 and Ang-2 [ 5 6 ] . Ang-1 has been shown to be responsible for recruiting and sustaining periendothelial support cells [ 7 ] . It has been reported that Ang-2 disrupts blood vessel formation in the developing embryo by antagonizing Ang-1-induced autophosphorylation of Tie2 [ 6 ] . Transgenic mouse models of Tie2/Ang-1 result in embryonic lethality due to absence of remodeling and sprouting of blood vessels [ 7 8 ] . The physiologic roles of the Tie2 receptor and its ligands are limited to angiogenic processes that occur subsequently to the earlier vasculogenic and angiogenic actions of vascular endothelial growth factor (VEGF) and its receptors [ 7 ] . VEGF and the Tie family orchestrate optimal blood vessel formation [ 9 10 ] .
The VEGF mRNA signal is apparent as a dark stain (panel A), and may be compared to the sense control (panel B) which shows no non-specific binding in the same muscle region.
Similar results were observed in VEGF (T1:T2 and T2:T3, p = 0.015; T1:T4, p = 0.014; T2:T4, p = 0.01, Table 5).
The identification of VEGFR-1 and VEGFR-2 (KDR) was consistent with the observation that the stimulation of ECs with VEGF increases the expression of VEGFR-2, promoting myocardial revascularization [ 22 ] . We also detected the cell adhesion molecules VCAM-1, VE-Cadherin, and the α 2 integrin subunit, all known regulators of angiogenesis.
In the present study we used a 1 hr. treadmill exercise protocol or a 1 hr. electrical stimulation protocol to upregulate total VEGF mRNA production in rat gastrocnemius muscle.
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