Example sentences for: v-crk

How can you use “v-crk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • By contrast, co-expression of these fusions along with v-crk results in stable tyrosine phosphorylation of the 3' C-terminal YDXP motifs and the full length Cas SD (carrying both motifs), but not the 5' N-terminal YQXP motifs (Fig.

  • By contrast, co-expression of v-crk with the chimera resulted in reduction in the association of v-crk with endogenous Cas and in induced association of v-crk with the tyrosine phosphorylated Cas 3'SD (Fig.

  • In particular, we found that the tyrosine phosphorylated Cas SD domain blocked v-crk mediated activation of the JNK pathway.

  • Figure 4ademonstrates that while the chimera was not stably tyrosine phosphorylated when expressed alone, expression of the Src KM/Cas(SD) chimera along with either WT or an SH3 domain mutant of v-crk resulted in its stable tyrosine phosphorylation and co-immunoprecipitation with v-crk (Fig.

  • These data indicate that the v-crk SH2 domain interacts with the C-terminal YDXP motifs, and as suggested by Birge et al, v-crk may be able to protect them from dephosphorylation and/or induces their phosphorylation [ 12 ] . They also suggest that the YQXP motifs may be involved in binding to other intracellular signaling molecules.


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