Words similar to v-crk

Example sentences for: v-crk

How can you use “v-crk” in a sentence? Here are some example sentences to help you improve your vocabulary:

Experiments used the chimeras expressed either via the pJ3H vector, or the HA-tagged chimera subcloned into the expression vector pMEXneo [ 48 ] . The oncogene v-crk and its mutants cloned into pMEXneo have been described [ 49 50 ] .
Such a mutant is inactive against exogenous substrates [ 34 35 36 ] . We found that this Src*/Cas(SD) molecule is constitutively tyrosine phosphorylated when expressed either transiently or stably in cells, and acts as a dominant negative mutant, attenuating v-crk mediated transformation when expressed in cells transformed by this oncogene.
We then used the 5' and 3' fusions of the Cas SD to determine which motif, YQXP or YDXP, interacts with the v-crk SH2 domain.
Thus, our data suggest that the tyrosine phosphorylated Cas SD acts as a decoy for endogenous Cas binding proteins and blocks signaling via crk to the activation of JNK, as well as transformation of cells by the oncogene v-crk.
By contrast, co-expression of v-crk with the chimera resulted in reduction in the association of v-crk with endogenous Cas and in induced association of v-crk with the tyrosine phosphorylated Cas 3'SD (Fig.