Words similar to urokinase
Example sentences for: urokinase
How can you use “urokinase” in a sentence? Here are some example sentences to help you improve your vocabulary:
As a standard we used urokinase or mhATF-BPTI.
One of great importance, urokinase (uPA) and its high affinity receptor, the GPI-anchored membrane CD87 (uPAR), is critical in tumour progression and its level of expression is correlated with poor prognosis of various cancers such as prostate [ 2 ] , breast [ 3 ] , colon [ 4 ] , ovarian [ 5 ] , gastric [ 6 ] , brain [ 7 ] , and lung cancer [ 8 ] . Urokinase (uPA) and its main product plasmin belong to the very early proteases [ 9 10 11 ] that activate the metallo-protease (MMP) cascade and therefore control cell motility, tissue remodelling and the activation of various angiogenic factors (VEGF, TGFβ).
The two major groups of proteinases involved in extracellular matrix degradation - serine proteinases and metalloproteinases - have been grouped by literature profiling (Figure 6b: urokinase plasminogen activation cascade (UPA, PLAUR, SERPIN) and matrix metalloproteinases (MMP14, MMP10, MMP1)).
This example illustrates how functional relationships that could not be deduced from gene names were uncovered through the analysis of patterns of term occurrence: matrix metalloproteinases (MMP1, 10, 14) and urokinase plasminogen activator (UPA, SPARC) are matrix-interacting molecules involved in tumor invasion and metastasis.
After 2 h of incubation at 37 °C, 50 μl detection reagent containing a modified urokinase and S-2444 peptide substrate was added to all wells.