Words similar to urokinase

Example sentences for: urokinase

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One of great importance, urokinase (uPA) and its high affinity receptor, the GPI-anchored membrane CD87 (uPAR), is critical in tumour progression and its level of expression is correlated with poor prognosis of various cancers such as prostate [ 2 ] , breast [ 3 ] , colon [ 4 ] , ovarian [ 5 ] , gastric [ 6 ] , brain [ 7 ] , and lung cancer [ 8 ] . Urokinase (uPA) and its main product plasmin belong to the very early proteases [ 9 10 11 ] that activate the metallo-protease (MMP) cascade and therefore control cell motility, tissue remodelling and the activation of various angiogenic factors (VEGF, TGFβ).
The ATF plasmid was constructed by deleting the DNA sequences encoding amino acids 139 to 401 of the urokinase cDNA plasmid.
Furthermore, mhATF-BPTI was shown to inhibit plasmin activity at the cell surface of rat aortic smooth muscle cells (RASMC) expressing rat urokinase receptor [ 21 ] .
uPA: Urokinase Plasminogen Activator
(TNO-Prevention and Health, Leiden The Netherlands), using a monoclonal antibody specific for the ATF as the capture antibody and a polyclonal antibody directed against BPTI as the detector antibody [ 24 ] . As a standard we used either urokinase or mhATF-BPTI.