Example sentences for: urokinase

How can you use “urokinase” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • As a standard we used urokinase or mhATF-BPTI.

  • One of great importance, urokinase (uPA) and its high affinity receptor, the GPI-anchored membrane CD87 (uPAR), is critical in tumour progression and its level of expression is correlated with poor prognosis of various cancers such as prostate [ 2 ] , breast [ 3 ] , colon [ 4 ] , ovarian [ 5 ] , gastric [ 6 ] , brain [ 7 ] , and lung cancer [ 8 ] . Urokinase (uPA) and its main product plasmin belong to the very early proteases [ 9 10 11 ] that activate the metallo-protease (MMP) cascade and therefore control cell motility, tissue remodelling and the activation of various angiogenic factors (VEGF, TGFβ).

  • The two major groups of proteinases involved in extracellular matrix degradation - serine proteinases and metalloproteinases - have been grouped by literature profiling (Figure 6b: urokinase plasminogen activation cascade (UPA, PLAUR, SERPIN) and matrix metalloproteinases (MMP14, MMP10, MMP1)).

  • This example illustrates how functional relationships that could not be deduced from gene names were uncovered through the analysis of patterns of term occurrence: matrix metalloproteinases (MMP1, 10, 14) and urokinase plasminogen activator (UPA, SPARC) are matrix-interacting molecules involved in tumor invasion and metastasis.

  • After 2 h of incubation at 37 °C, 50 μl detection reagent containing a modified urokinase and S-2444 peptide substrate was added to all wells.


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