Words similar to unique
Example sentences for: unique
How can you use “unique” in a sentence? Here are some example sentences to help you improve your vocabulary:
The natural phenomenon of spontaneous mutation, which occurs in the absence of drug selection, results in the accumulation of approximately six to eight TK-deficient variants per 10 4plaque-forming viruses in virus populations that have never been exposed to selective pressure [ 6 10 12 ] . Furthermore, HSV-2 clinical isolates were shown to have a higher frequency of spontaneous mutations resistant to ACV and PCV, approximately 30-fold, compared to HSV-1 isolates, and the majority of these mutations are in tk . Consistent with this observation, HSV-2 strains also exhibited approximately a 20- to 80-fold higher spontaneous mutation rate to cidofovir (HPMPC), an inhibitor of HSV Pol, resistance compared with HSV-1 [ 21 ] . Therefore, these naturally-occuring mutations are not unique to tk and TK substrates as detected with antiviral agents ACV and PCV, but were extended with the direct Pol inhibitor, HPMPC, to other loci, most likely pol .
A question that arises in analyzing eukaryotic sequences with strong matches to bacterial proteins, especially when the match is unique, is whether the gene in question truly was isolated from a eukaryote, or whether it represents a prokaryotic contaminant (any nucleic acid matches of ESTs to prokaryotes, which probably would be contaminants, were removed before database submission [ 28 ] ). Claims of nematode genes having been acquired by HGT [ 17 18 19 23 ] have addressed this issue in a number of ways.
Rab24 contains a unique arginine-rich insert, 126EEDRRRRR 133 [ 25 ] in the domain cognate to loop-8 in H-Ras [ 34 ] . The latter sequence is reminiscent of unusual arginine-rich nuclear localization signals that allow proteins like HIV tet and rev to undergo nuclear translocation by association with importin-β, in the absence of importin-α [ 45 46 ] . Since the loop-8 insert in Rab24 lies adjacent to the conserved N(T)KxD nucleotide binding cassette, we hypothesized that conformational changes caused by the D123I substitution might render the Rab24 mutant capable of disrupting the nuclear import machinery [ 47 ] . To test this possibility, we co-expressed mycRab24wt or mycRab24(D123I) with GR-GFP, a fusion between the glucocorticoid receptor and green fluorescent protein.
(DNA, like fingerprints, is unique to each individual.)
Gene products of these paralogous genes contained a unique bi-lobed hydrophobic domain, which is a predictive marker for localization to the inclusion membrane [ 15 ] . In this study, we further characterize this family by examining variation in sequence of the family members both within and among different C. pneumoniae isolates.
Loading...