Words similar to txa
Example sentences for: txa
How can you use “txa” in a sentence? Here are some example sentences to help you improve your vocabulary:
TXA 2 production tended to be greater in IPF than in normal fibroblasts at baseline; when stimulated with IL-1β this difference became statistically significant.
IL-1β-stimulated production of TXB 2 (stable metabolite of the active TXA
On the other hand, PGI 2 decreases vascular smooth muscle cell proliferation and collagen and glycosaminoglycane synthesis, via activation of adenylyl cyclase and subsequent production of cAMP [ 17 ] . Betaprost, an analog of PGI 2 , decreases procollagen I and III mRNA expression in cardiac fibroblasts [ 18 ] . These effects may counteract the profibrotic effects seen with TXA 2 and it is possible that an alteration of a "normal" physiologic balance between PGI 2 and TXA 2 could increase tendency towards fibrogenesis.
TxA 2 is a product of arachidonic acid and a potent platelet aggregator, whose levels increase during endotoxic shock.
The above results suggest that a decreased PGI 2 :TXA 2 ratio could be a phenotypic alteration present in IPF fibroblasts, resulting in a loss of their capacity to autoregulate proliferation and extracellular matrix production.