Example sentences for: tsp-
How can you use “tsp-” in a sentence? Here are some example sentences to help you improve your vocabulary:
The effect of TSP-1 expression on tumor growth and metastasis has been examined in vivo by orthotopic inoculation of TSP-1-overexpressing MDA-MB-435 cells.
CD36 is widely expressed and may interact with multiple extracellular ligands, including thrombospondin-1 (TSP-1), long-chain free fatty acids (FFAs), modified (oxidized) low-density lipoprotein (ox-LDL), advanced glycation end (AGE) products, and collagens I and IV [6].
Our LCM-mediated transcript detection acts as an important confirmation of breast tumor cell OPN synthesis because IHC analysis does not rule out the possibility that secreted proteins such as OPN and TSP-1 are sequestered by the tumor cells from the local environment.
Having detected all three proteins immunohistochemically in normal, benign and malignant breast epithelia, the quantitation of OPN, TSP-1 and TYRP-1 mRNA was achieved using LCM and qPCR.
A recent study confirms this to be the case in breast cancer, where expression of TSP-1 in stroma adjacent to ductal carcinoma in situ is lost in cases with more aggressive histological features [ 30 ] . There are also reports, however, that fibroblast TSP-1 can induce matrix metalloproteinase-9 in breast tumor cells and gastric cancer tumor cells, and this in turn may lead to a more invasive phenotype [ 14 31 ] . In the present study, TSP-1 was not expressed differentially in the stroma of benign tissue specimens or malignant tissue specimens, nor in the epithelial component of breast tumors with or without metastases.
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