Words similar to trβ

Example sentences for: trβ

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Finally, mutations within the β-box (especially M2405A, L2406A) disrupted ERβ interactions with N-CoR in mammalian two-hybrid assays, but did not affect TRβ interactions (Fig.
The following plasmids (pSG5-ERα, pSG5-ERβ (amino acids 1-530) [ 31 ] , pGEX-N-CoR and pGEX-SMRT [ 39 ] , VP16-TRβ and Gal-N-CoR [ 16 ] , GST-N-CoR fusions [ 17 ] , ERE-LUC, GK1/Gal4 responsive reporter and Gal-ERα LBD [ 53 ] , pM-D2, pM-D47, pM-F6 [ 46 ] ) have been previously described.
Control two-hybrid assays confirmed that a VP16-TRβ LBD fusion protein bound N-CoR in the absence of hormone, but not in the presence of T3.
The Gal-β-box fusion failed to recruit the ERα, TRβ or RARβ LBDs in mammalian two-hybrid assays (Fig.
1D) and that TRβ bound N-CoR in the absence of hormone, and was released in the presence of T3, whereas TRβ only bound GRIP1 in the presence of T3 (Fig.