Words similar to trs

Example sentences for: trs

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Generally, NR transcriptional activity is dictated by the balance between coactivator and corepressor recruitment, and one of the most important factors that influences this balance is the absence or presence of agonist ligands (reviewed in [ 4 ] ). Unliganded NRs such as thyroid (TRs) and retinoid receptors (RARs) bind corepressors, and ligand promotes release of corepressor and subsequent binding of coactivators.
In any case, the fact that ERβ binds weakly or not at all to the three N-CoR ID motifs that mediate interactions with TRs and RARs and, instead, binds in an agonist-dependent fashion to a region in the C-terminus of N-CoR that has not previously been implicated in NR interactions indicates that ERβ recognizes a novel protein sequence motif within N-CoR.