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Example sentences for: trnas
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Release 1 reported 292 tRNAs [ 3]; two tRNA genes were deleted as a result of sequence finishing resolving repeated regions of the genome.
Assuming that the ancestor had the same complement of tRNAs as E. coli, 15 were lost from within syntenic fragments and 39 were lost in regions between syntenic fragments.
We searched for new tRNA genes using the program tRNAscan-SE [ 32] and Sim4 alignments to known tRNAs: 290 are annotated in the euchromatin (Table 2).
Although the region is not bracketed by IS elements or tRNAs that are characteristic of pathogenicity islands (PAIs), it bears features that are similar to the putative PAI identified in the B. anthracis plasmid pXO1 [ 20 ] . Bacterial sequences with similarity to the B. anthracis cap genes are present in sequence databases.
Along these lines, when the aminogylcosides (kanamycin, hygromycin B, paromycin and neomycin) due to their ability to inhibit protein synthesis by affecting ribosomal fidelity, or puromycin because of its competing ability with tRNAs for binding on the large ribosomal subunit, or cycloheximide which inhibit the large ribosomal subunit by preventing ribosomal movement along the mRNA, were used in active HIV-1 infection, it was found that both cycloheximide and puromycin produced the greatest decrease in HIV-1 inhibition, presumably by inhibiting the large subunit of the ribosome [ 41 ] .
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