Example sentences for: transgene

How can you use “transgene” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Tag-TCR1 (referred to hereafter as TCR) transgenic mice expressing a T cell receptor transgene with specificity to Tag were generated in the B6D2F1 background and backcrossed to C3HeBFe for 20 generations [ 28 ] . About 10% of the splenic CD4 +T cells in this transgenic line express the TCR transgene [ 28 ] . All Rip1-Tag2 in all treatment groups received the same diet throughout the experiment.

  • In males, further increasing expression by using two copies of the UAS-mCul1 transgene reduces the wing to a rudimentary stump (not shown).

  • Five each of Pten +/- mice without a Wnt-1 transgene were monitored for 7 months and 10.

  • Wnt signaling is known to play a critical role in the development of the brain, and the midbrain and cerebellum do not form in animals lacking Wnt-1 [ 23 ] . Furthermore, targeted disruption of the frizzled-4 gene results in cerebellar abnormalities in mice [ 24 ] . Transgene expression from the PrP promoter is extremely low during embryonic development, with high-level postnatal expression largely restricted to neurons and glia of the CNS [ 25 ] . Transgenic mice expressing either wild-type or mutant β-catenin were generated so that a range of pathway activation could be examined.

  • Recent data from our laboratory have shown that the synovial lining is capable of maintaining therapeutic levels of transgene expression for at least 6 months [ 28 ] , providing increased optimism for the use of gene transfer in the treatment of chronic articular disease.


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