Example sentences for: topo

How can you use “topo” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It is commonly used in in vitro experimental model systems to study the mechanisms of action of Topo I inhibitors.

  • Only limited side effects, such as manageable neutropenia, in patients who received high doses of Topo I inhibitors have been reported [ 16, 17].

  • 1TOPO (Invitrogen; acute O 3 library) or the Advantage PCR cloning vector (Clontech; all the other libraries) according to manufacturer's instructions.

  • The gel-purified PCR products were cloned into either a pSTBlue-1 vector (Novagen, Madison, WI) or pCR 4-TOPO TA vector (Invitrogen, Carlsbad, CA), according to the manufacturer's protocol.

  • Since many neoplastic cells are characterized by high levels and/or activities of Topo I [ 14, 15], this enzyme has become one of the cellular targets for anticancer therapy [ 16, 17].


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