Example sentences for: topo

How can you use “topo” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Clinically approved Topo I inhibitors, irinotecan and topotecan, are semisynthetic derivatives of CPT that differ from CPT in toxicity profiles and water solubility but not in the mechanisms of action [ 16, 17].

  • Camptothecin (CPT) and its derivatives specifically target Topo I by binding noncovalently to these cleavable complexes, stabilizing them and interfering with DNA religation [ 11].

  • 1-TOPO cloning vector (Invitrogen).

  • Only limited side effects, such as manageable neutropenia, in patients who received high doses of Topo I inhibitors have been reported [ 16, 17].

  • The amplified cDNA was cloned using the Invitrogen TOPO Cloning kit.


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