Example sentences for: topo

How can you use “topo” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We used human insulin cDNA (320 bp) cloned in plasmid pCR4-TOPO (Invitrogen) as a template for in vitro transcription to produce riboprobes with a digoxigenin-RNA labeling kit (Ambion, Austin, Texas, United States), performed hybridization with IPC cluster sections as described [16], and used DIG Nucleic Acid Detection Kit (Roche, Indianapolis, Indiana, United States) for development according to the manufacturer's instructions.

  • DNA Topo I is an essential enzyme involved in such crucial cellular functions as replication and transcription.

  • We have focused on the effects of the leading Topo I inhibitor, CPT, on collagen production by dermal fibroblasts obtained from patients with SSc.

  • This study was undertaken to determine whether inhibition of its activity by noncytotoxic doses of CPT, a drug that selectively targets Topo I, could reverse the activated phenotype of fibroblasts from patients with SSc.

  • It is commonly used in in vitro experimental model systems to study the mechanisms of action of Topo I inhibitors.


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