Words similar to tnfr-

Example sentences for: tnfr-

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In contrast, mice deficient in TTP and TNFR-2 show a more severe phenotype, suggesting a protective role for this receptor [ 27 ] .
report a close relationship between IL-8 secretion in cystic fibrosis cells and expression of genes from the TNFR-1/NFkB pathway.
TNF-α is a well-characterized, potent inducer of IL-8 transcription and an anti-apoptotic agent [ 30 31 32 ] . Roebuck provides a detailed analysis of IL-8 promoter structure including a promoter recruitment mechanism which involves TNF-α and the cooperativity of NF-kB and NF-IL-6 binding sites [ 4 32 ] . TNF-α exerts many of its effects through TNFR-1 and TNFR-2 receptors, thus co-expression of these receptors with IL-8 might be anticipated.
As is the case for several other genes found in this study, the TNFR-1/NFkB pathway is associated with p53/p21 WAF-1tumor suppressor systems [ 33 34 35 36 37 ] .
This is not a TNF-dependent effect, since the phenotype is not affected by the removal of either TNFR-1 or -2 or by the addition of TNF antibody [ 27 ] . Recent studies have suggested a potential interaction between TTP and both IL-3 and IL-8 via the ARE in their mRNA [ 29 30 ] .